Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
基本信息
- 批准号:RGPIN-2016-05685
- 负责人:
- 金额:$ 2.77万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Glass and ceramic materials are used in a wide array of applications, from screens on mobile devices, to the crowns used by dentists to repair teeth. More recently glass products have been used to repair bones, and treat cancers. However, the ability to specifically tailor and engineer glasses that can degrade at various time frames, from weeks, to months, to years, has long been a challenge in the natural sciences; even though conquering this challenge would open significant benefits in industrial and biomedical engineering. Interestingly, the glass systems that might provide for these features account for less than 2% of glass research worldwide. We propose to redress the balance. We will examine ways to modulate and predict the molecular architecture and physical chemistry of degradable glasses using unique glass compositions that have never previously been reported, nor catalogued, with any of the international agencies or journals. We will use statistical design methods to invent new glasses and ceramic systems, then we will probe their molecular structure and degradation behavior using state of the art techniques and mathematical modelling to build predictive models that will show other researchers how to design-in' a preferred rate of degradation to a particular material. We intend to achieve these variable rates of degradation by adding biologically important elements into the materials structure to modulate their molecular architecture, and as such, their degradation behavior. In addition, this approach will also enable us to investigate if the elements released from a glass, while degrading, can trigger physiological systems to self repair and regenerate.**
玻璃和陶瓷材料应用广泛,从移动的设备上的屏幕,到牙医用来修复牙齿的牙冠。最近,玻璃产品已被用于修复骨骼和治疗癌症。然而,专门定制和设计可以在不同时间范围内降解的眼镜的能力,从几周到几个月,再到几年,一直是自然科学领域的一个挑战;尽管克服这一挑战将为工业和生物医学工程带来重大利益。有趣的是,可能提供这些功能的玻璃系统占全球玻璃研究的不到2%。我们建议纠正这种平衡。我们将研究如何调节和预测可降解玻璃的分子结构和物理化学,使用以前从未报道过的独特玻璃组合物,也没有编目,与任何国际机构或期刊。我们将使用统计设计方法来发明新的玻璃和陶瓷系统,然后我们将使用最先进的技术和数学建模来探测它们的分子结构和降解行为,以建立预测模型,向其他研究人员展示如何设计特定材料的首选降解速率。我们打算通过在材料结构中添加生物学重要元素来调节其分子结构,从而实现这些可变的降解速率,并因此调节其降解行为。此外,这种方法还将使我们能够调查从玻璃中释放的元素在降解的同时是否可以触发生理系统进行自我修复和再生。
项目成果
期刊论文数量(0)
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Boyd, Daniel其他文献
Characterization of glycation in an IgG1 by capillary electrophoresis sodium dodecyl sulfate and mass spectrometry
- DOI:
10.1016/j.ab.2011.06.024 - 发表时间:
2011-10-15 - 期刊:
- 影响因子:2.9
- 作者:
Kaschak, Timothy;Boyd, Daniel;Yan, Boxu - 通讯作者:
Yan, Boxu
Modulation of strontium release from a tertiary borate glass through substitution of alkali for alkali earth oxide
- DOI:
10.1016/j.jnoncrysol.2016.04.024 - 发表时间:
2016-07-01 - 期刊:
- 影响因子:3.5
- 作者:
MacDonald, Kathleen;Hanson, Margaret A.;Boyd, Daniel - 通讯作者:
Boyd, Daniel
The effect of composition and annealing on the properties of aluminum free GPCs: A preliminary evaluation
- DOI:
10.1016/j.matlet.2014.05.025 - 发表时间:
2014-08-15 - 期刊:
- 影响因子:3
- 作者:
Dickey, Brett;Lee, Amanda;Boyd, Daniel - 通讯作者:
Boyd, Daniel
Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1
- DOI:
10.1074/jbc.m111.311811 - 发表时间:
2012-02-17 - 期刊:
- 影响因子:4.8
- 作者:
Yan, Boxu;Boyd, Daniel;Amanullah, Ashraf - 通讯作者:
Amanullah, Ashraf
HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region
- DOI:
10.1016/j.jchromb.2011.03.006 - 发表时间:
2011-04-15 - 期刊:
- 影响因子:3
- 作者:
Boyd, Daniel;Kaschak, Timothy;Yan, Boxu - 通讯作者:
Yan, Boxu
Boyd, Daniel的其他文献
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{{ truncateString('Boyd, Daniel', 18)}}的其他基金
Screening, Modelling and Optimization of Soluble Medical Glasses & Ceramics
可溶医用玻璃的筛选、建模和优化
- 批准号:
RGPIN-2022-03371 - 财政年份:2022
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
- 批准号:
RGPIN-2016-05685 - 财政年份:2021
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
- 批准号:
RGPIN-2016-05685 - 财政年份:2020
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
- 批准号:
RGPIN-2016-05685 - 财政年份:2018
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Phase 1: Development of degradable and multimodal imageable microspheres for transfer to medical device industry
第一阶段:开发可降解和多模态可成像微球,用于转移到医疗器械行业
- 批准号:
505848-2017 - 财政年份:2017
- 资助金额:
$ 2.77万 - 项目类别:
Idea to Innovation
Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
- 批准号:
RGPIN-2016-05685 - 财政年份:2017
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Predictive Modelling in the Fundamental Science of Medical Ceramics
医用陶瓷基础科学中的预测模型
- 批准号:
RGPIN-2016-05685 - 财政年份:2016
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Therapeutic and regenerative glass based biomaterials
治疗性和再生性玻璃基生物材料
- 批准号:
386022-2010 - 财政年份:2014
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Therapeutic and regenerative glass based biomaterials
治疗性和再生性玻璃基生物材料
- 批准号:
386022-2010 - 财政年份:2013
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
Therapeutic and regenerative glass based biomaterials
治疗性和再生性玻璃基生物材料
- 批准号:
386022-2010 - 财政年份:2012
- 资助金额:
$ 2.77万 - 项目类别:
Discovery Grants Program - Individual
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