Functional architecture of the cortical memory network
皮质记忆网络的功能架构
基本信息
- 批准号:RGPIN-2015-05458
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Memories of daily experiences are vital to our day-to-day living. The long-term goal of my research is to uncover how these memories emerge from the coordinated activity of brain cells. During the past ten years, I have used a simple associative memory paradigm in rats, called trace eyeblink conditioning, and identified that the associative memory initially depends on a brain region called the hippocampus, but with time it comes to depend on another brain region called the medial prefrontal cortex (mPFC). With the last five years of NSERC funding, my research team identified that another brain region, the entorhinal cortex (EC) plays an important role for the memory by initially interacting with the hippocampus, but later with the mPFC. In the next five years, we will expand these findings with three parallel studies. First, we will examine how neurons in the EC respond to several variables which consist of an experience in trace eyeblink conditioning. This will identify the most relevant variable for the memory representation in the EC. Second, we will examine a mechanism which allows for a better coordination of EC and mPFC for older memories. Specifically, we will determine whether connections between neurons in the EC and mPFC are strengthened as the associative memory is stabilized. In parallel, we will reversibly cut the connection between the EC and mPFC while the associative memory is stabilized and examine the impact of the manipulation on animals' ability to later recall the memory. Lastly, we will identify a specific activity pattern of brain cells which is responsible for the formation of memory. Our past studies reported that cells in the mPFC show several patterns of activity while rats form associative memory in trace eyeblink conditioning. But, a question is whether the memory is formed because of these activity patterns. To address this point, we will test whether the associative memory is formed when the cells in the mPFC are stimulated as the same pattern as those observed during normal memory formation. Together, these studies combine state-of-art approaches to provide new insights into how brain cells represent and compute memories. By doing so, the proposed studies will bring us a step closer toward a mechanistic account of our fundamental cognitive ability.
日常经历的记忆对我们的日常生活至关重要。我研究的长期目标是揭示这些记忆是如何从脑细胞的协调活动中产生的。在过去的十年里,我在大鼠身上使用了一种简单的联想记忆范式,称为跟踪眨眼条件反射,并发现联想记忆最初取决于一个名为海马体的大脑区域,但随着时间的推移,它开始依赖于另一个名为内侧前额叶皮层(mPFC)的大脑区域。在过去五年的NSERC资助下,我的研究团队发现,另一个大脑区域,内嗅皮层(EC)通过最初与海马体相互作用,但后来与mPFC相互作用,对记忆起着重要作用。在接下来的五年里,我们将通过三项平行研究来扩展这些发现。首先,我们将研究EC中的神经元如何对几个变量做出反应,这些变量包括跟踪眨眼条件反射的经验。这将识别EC中与内存表示最相关的变量。其次,我们将研究一种机制,它允许更好地协调EC和mPFC的旧记忆。具体来说,我们将确定EC和mPFC中的神经元之间的连接是否随着联想记忆的稳定而加强。与此同时,我们将可逆地切断EC和mPFC之间的连接,而联想记忆是稳定的,并检查操纵对动物的能力的影响,后来回忆的记忆。最后,我们将确定负责记忆形成的脑细胞的特定活动模式。我们过去的研究发现,大鼠在眨眼条件反射条件下形成联想记忆时,前额叶皮层细胞表现出多种活动模式。但是,一个问题是,记忆是否是因为这些活动模式而形成的。为了解决这一点,我们将测试当mPFC中的细胞被刺激时是否形成联想记忆,其模式与正常记忆形成期间观察到的模式相同。总之,这些研究结合了联合收割机最先进的方法,为脑细胞如何代表和计算记忆提供了新的见解。通过这样做,拟议中的研究将使我们更接近于对我们基本认知能力的机械解释。
项目成果
期刊论文数量(0)
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TakeharaNishiuchi, Kaori其他文献
TakeharaNishiuchi, Kaori的其他文献
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{{ truncateString('TakeharaNishiuchi, Kaori', 18)}}的其他基金
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPAS-2020-00023 - 财政年份:2022
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPIN-2020-04479 - 财政年份:2022
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPAS-2020-00023 - 财政年份:2021
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPIN-2020-04479 - 财政年份:2021
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPAS-2020-00023 - 财政年份:2020
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPIN-2020-04479 - 财政年份:2020
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical memory network
皮质记忆网络的功能架构
- 批准号:
RGPIN-2015-05458 - 财政年份:2018
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical memory network
皮质记忆网络的功能架构
- 批准号:
RGPIN-2015-05458 - 财政年份:2017
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical memory network
皮质记忆网络的功能架构
- 批准号:
RGPIN-2015-05458 - 财政年份:2016
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical memory network
皮质记忆网络的功能架构
- 批准号:
RGPIN-2015-05458 - 财政年份:2015
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
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支持关系记忆的皮质网络的功能架构
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支持关系记忆的皮质网络的功能架构
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Discovery Grants Program - Individual
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支持关系记忆的皮质网络的功能架构
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Functional architecture of the cortical network supporting relational memory
支持关系记忆的皮质网络的功能架构
- 批准号:
RGPIN-2020-04479 - 财政年份:2020
- 资助金额:
$ 2.91万 - 项目类别:
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Functional architecture of the cortical memory network
皮质记忆网络的功能架构
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- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Functional architecture of the cortical memory network
皮质记忆网络的功能架构
- 批准号:
RGPIN-2015-05458 - 财政年份:2017
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual