Optical and dosimetric technologies for radiation therapy

用于放射治疗的光学和剂量测定技术

基本信息

  • 批准号:
    RGPIN-2015-04744
  • 负责人:
  • 金额:
    $ 3.06万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Lifetime cancer incidence rates in Canada are estimated at 40%. As approximately one half of all cancer patients will receive radiation therapy (RT), improvements in treatment efficacy will positively impact a large number of patients. This proposal outlines two main areas of RT research that address persistent bottlenecks in basic knowledge in biological and technical aspects of RT: (i) the use of optical techniques for developing a deep understanding and monitoring of biological response to radiation and (ii) development and application of radiation measurement tools for use in RT.***RAMAN SPECTROSCOPY FOR UNDERSTANDING AND MONITORING BIOLOGICAL RESPONSE IN RT***INTRODUCTION: My group has developed optical technologies capable of observing radiation damage in cells over clinically relevant timeframes. A current limitation of the experimental system is the long data collection times and user-specific expertise required to acquire a relatively small amount of data.***OBJECTIVES: (i) To develop an automated data collection system utilizing our current system and small-sample fluid flow channels (microfluidics). (ii) To develop advanced data analysis techniques for information extraction from the system developed in aim (i). ***IMPACT: RT prescriptions are currently based on prior population outcomes, with minimal consideration given to individual patient radiation response. There exist no accepted methods for understanding individual patient biological response or in monitoring of the efficacy of treatment during the course of RT. An automated data collection system with advanced data analysis capabilities will pave the path towards understanding individual patient biological response and in the monitoring of treatment efficacy during the course of RT, enabling oncologists to tune radiation dose based on treatment progression.***3D RADIATION DOSIMETER DEVELOPMENT***INTRODUCTION: Polymer gel dosimeters (PGD) are a promising tool for 3D dose measurement and stand to revolutionize further innovations in RT delivery. However, PGD have not been fully developed for clinical use.  ***OBJECTIVES: (i) To establish an accurate and robust PGD system for further research in 3D radiation dosimetry. (ii) To apply the system to full patient RT process verification and to the verification of novel dose calculation algorithms. ***IMPACT: The current complexity in RT delivery has outpaced the development of 3D dose measurement instrumentation, thus limiting further innovation in RT delivery. PGD is an attractive 3D dosimetry technique due to the wealth of dosimetric information afforded by the technique.  Establishing a robust PGD system is critical for enabling clinical acceptance of this tool. This work stands to significantly impact the understanding of currently delivered 3D radiation doses, thus enabling the next generation of RT treatment development.**
加拿大的终生癌症发病率估计为40%。由于大约一半的癌症患者将接受放射治疗(RT),治疗效果的改善将对大量患者产生积极影响。本提案概述了RT研究的两个主要领域,以解决RT生物学和技术方面基础知识的持续瓶颈:(i)使用光学技术来深入了解和监测生物对辐射的反应;(ii)开发和应用辐射测量工具用于RT。***拉曼光谱用于了解和监测RT中的生物反应***简介:我的团队开发了能够在临床相关时间框架内观察细胞辐射损伤的光学技术。目前实验系统的一个限制是数据收集时间长,需要用户特定的专业知识才能获得相对较少的数据。***目标:(i)利用我们现有的系统和小样本流体流动通道(微流体)开发一个自动数据收集系统。(ii)开发先进的数据分析技术,从目标(i)中开发的系统中提取信息。***影响:RT处方目前基于先前的人群结果,很少考虑个体患者的放射反应。目前还没有公认的方法来了解个体患者的生物反应或监测放疗过程中的治疗效果。具有先进数据分析能力的自动数据收集系统将为了解个体患者的生物反应和监测放疗过程中的治疗效果铺平道路,使肿瘤学家能够根据治疗进展调整辐射剂量。***介绍:聚合物凝胶剂量计(PGD)是一种很有前途的3D剂量测量工具,并将在放射治疗领域进一步革新。然而,PGD尚未完全发展到临床应用。***目的:(i)为进一步研究三维辐射剂量学建立准确、可靠的PGD系统。(ii)将该系统应用于全患者放射治疗过程验证和新型剂量计算算法验证。***影响:目前放射治疗的复杂性已经超过了3D剂量测量仪器的发展,从而限制了放射治疗的进一步创新。PGD是一种有吸引力的三维剂量学技术,因为该技术提供了丰富的剂量学信息。建立一个强大的PGD系统对于临床接受该工具至关重要。这项工作将显著影响对目前提供的3D辐射剂量的理解,从而使下一代放射治疗的发展成为可能

项目成果

期刊论文数量(0)
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Jirasek, Andrew其他文献

Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro: Correlation with Cell Cycle and Culture Confluency
  • DOI:
    10.1366/000370210792080966
  • 发表时间:
    2010-08-01
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Matthews, Quinn;Jirasek, Andrew;Brolo, Alexandre G.
  • 通讯作者:
    Brolo, Alexandre G.
Delivered Dose Distribution Visualized Directly With Onboard kV-CBCT: Proof of Principle
Raman microspectroscopy and machine learning for use in identifying radiation-induced lung toxicity.
  • DOI:
    10.1371/journal.pone.0279739
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Ali-Adeeb, Ramie N.;Shreeves, Phil;Deng, Xinchen;Milligan, Kirsty;Brolo, Alex G.;Lum, Jullian J.;Haston, Christina;Andrews, Jeffrey L.;Jirasek, Andrew
  • 通讯作者:
    Jirasek, Andrew
Monitor Ionizing Radiation-Induced Cellular Responses with Raman Spectroscopy, Non-Negative Matrix Factorization, and Non-Negative Least Squares
  • DOI:
    10.1177/0003702820906221
  • 发表时间:
    2020-03-18
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Deng, Xinchen;Ali-Adeeb, Ramie;Jirasek, Andrew
  • 通讯作者:
    Jirasek, Andrew
Prediction of disease progression indicators in prostate cancer patients receiving HDR-brachytherapy using Raman spectroscopy and semi-supervised learning: a pilot study.
  • DOI:
    10.1038/s41598-022-19446-4
  • 发表时间:
    2022-09-06
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Milligan, Kirsty;Deng, Xinchen;Ali-Adeeb, Ramie;Shreeves, Phillip;Punch, Samantha;Costie, Nathalie;Crook, Juanita M.;Brolo, Alexandre G.;Lum, Julian J.;Andrews, Jeffrey L.;Jirasek, Andrew
  • 通讯作者:
    Jirasek, Andrew

Jirasek, Andrew的其他文献

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{{ truncateString('Jirasek, Andrew', 18)}}的其他基金

Development of optical spectroscopic and 3D dosimetric systems in radiation therapy
放射治疗中光学光谱和 3D 剂量测定系统的开发
  • 批准号:
    RGPIN-2020-07232
  • 财政年份:
    2022
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Development of optical spectroscopic and 3D dosimetric systems in radiation therapy
放射治疗中光学光谱和 3D 剂量测定系统的开发
  • 批准号:
    RGPIN-2020-07232
  • 财政年份:
    2020
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Optical and dosimetric technologies for radiation therapy
用于放射治疗的光学和剂量测定技术
  • 批准号:
    RGPIN-2015-04744
  • 财政年份:
    2018
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Optical and dosimetric technologies for radiation therapy
用于放射治疗的光学和剂量测定技术
  • 批准号:
    RGPIN-2015-04744
  • 财政年份:
    2017
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Optical and dosimetric technologies for radiation therapy
用于放射治疗的光学和剂量测定技术
  • 批准号:
    RGPIN-2015-04744
  • 财政年份:
    2016
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Collaborations in medical radiation beams for cancer therapy
癌症治疗医学放射束方面的合作
  • 批准号:
    498782-2016
  • 财政年份:
    2016
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Connect Grants Level 1
Optical fibre detectors for radiation beam characterization and dosimetry
用于辐射束表征和剂量测定的光纤探测器
  • 批准号:
    507425-2016
  • 财政年份:
    2016
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Engage Grants Program
Optical and dosimetric technologies for radiation therapy
用于放射治疗的光学和剂量测定技术
  • 批准号:
    RGPIN-2015-04744
  • 财政年份:
    2015
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Moving forward in radiation therapy: Dose verification and mapping cellular response
放射治疗的进展:剂量验证和细胞反应图谱
  • 批准号:
    311877-2010
  • 财政年份:
    2014
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual
Moving forward in radiation therapy: Dose verification and mapping cellular response
放射治疗的进展:剂量验证和细胞反应图谱
  • 批准号:
    311877-2010
  • 财政年份:
    2014
  • 资助金额:
    $ 3.06万
  • 项目类别:
    Discovery Grants Program - Individual

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Dosimetric characterization of modified radiochromic materials
改性放射变色材料的剂量学表征
  • 批准号:
    495289
  • 财政年份:
    2023
  • 资助金额:
    $ 3.06万
  • 项目类别:
Quantification of Dosimetric Errors from CT for Radiation Therapy Planning and Multicenter Evaluation of Dual-Energy CT
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  • 批准号:
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    2022
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    $ 3.06万
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将心脏电压图转换为 DICOM,用于室性心动过速立体定向消融患者的回顾性剂量电压分析和前瞻性放射治疗计划
  • 批准号:
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  • 财政年份:
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Optical and dosimetric technologies for radiation therapy
用于放射治疗的光学和剂量测定技术
  • 批准号:
    RGPIN-2015-04744
  • 财政年份:
    2018
  • 资助金额:
    $ 3.06万
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    Discovery Grants Program - Individual
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