Optical and dosimetric technologies for radiation therapy

用于放射治疗的光学和剂量测定技术

• 批准号: RGPIN-2015-04744
• 负责人: Jirasek, Andrew
• 金额: $ 3.06万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=613137
• 关键词: Optical; dosimetric; technologies; radiation; therapy

Lifetime cancer incidence rates in Canada are estimated at 40%. As approximately one half of all cancer patients will receive radiation therapy (RT), improvements in treatment efficacy will positively impact a large number of patients. This proposal outlines two main areas of RT research that address persistent bottlenecks in basic knowledge in biological and technical aspects of RT: (i) the use of optical techniques for developing a deep understanding and monitoring of biological response to radiation and (ii) development and application of radiation measurement tools for use in RT. RAMAN SPECTROSCOPY FOR UNDERSTANDING AND MONITORING BIOLOGICAL RESPONSE IN RT INTRODUCTION: My group has developed optical technologies capable of observing radiation damage in cells over clinically relevant timeframes. A current limitation of the experimental system is the long data collection times and user-specific expertise required to acquire a relatively small amount of data. OBJECTIVES: (i) To develop an automated data collection system utilizing our current system and small-sample fluid flow channels (microfluidics). (ii) To develop advanced data analysis techniques for information extraction from the system developed in aim (i).  IMPACT: RT prescriptions are currently based on prior population outcomes, with minimal consideration given to individual patient radiation response. There exist no accepted methods for understanding individual patient biological response or in monitoring of the efficacy of treatment during the course of RT. An automated data collection system with advanced data analysis capabilities will pave the path towards understanding individual patient biological response and in the monitoring of treatment efficacy during the course of RT, enabling oncologists to tune radiation dose based on treatment progression. 3D RADIATION DOSIMETER DEVELOPMENT INTRODUCTION: Polymer gel dosimeters (PGD) are a promising tool for 3D dose measurement and stand to revolutionize further innovations in RT delivery. However, PGD have not been fully developed for clinical use.   OBJECTIVES: (i) To establish an accurate and robust PGD system for further research in 3D radiation dosimetry. (ii) To apply the system to full patient RT process verification and to the verification of novel dose calculation algorithms.  IMPACT: The current complexity in RT delivery has outpaced the development of 3D dose measurement instrumentation, thus limiting further innovation in RT delivery. PGD is an attractive 3D dosimetry technique due to the wealth of dosimetric information afforded by the technique.  Establishing a robust PGD system is critical for enabling clinical acceptance of this tool. This work stands to significantly impact the understanding of currently delivered 3D radiation doses, thus enabling the next generation of RT treatment development.

加拿大的终生癌症发病率估计为40%。由于大约一半的癌症患者将接受放射治疗（RT），治疗效果的改善将对大量患者产生积极影响。该提案概述了RT研究的两个主要领域，解决了RT生物和技术方面基础知识的持续瓶颈：（i）使用光学技术深入了解和监测辐射生物反应;（ii）开发和应用RT中使用的辐射测量工具。 拉曼光谱用于实时生物反应的研究 简介：我的团队已经开发出能够在临床相关的时间范围内观察细胞辐射损伤的光学技术。实验系统目前的局限性是数据收集时间长，需要用户特定的专业知识来获取相对少量的数据。 （i）利用我们现有的系统和小样本流体流动通道（微流体）开发自动数据收集系统。(ii)发展先进的数据分析技术，以便从目标（一）所开发的系统中提取信息。 影响：RT处方目前基于既往人群结局，对个体患者辐射反应的考虑最少。目前还没有公认的方法来了解个别患者的生物反应或监测的治疗效果的过程中的RT。一个自动化的数据收集系统与先进的数据分析能力将铺平道路，了解个别患者的生物反应和监测的治疗效果的过程中的RT，使肿瘤学家调整辐射剂量的基础上治疗进展。 三维辐射剂量计的研制 简介：聚合物凝胶剂量计（PGD）是一种很有前途的三维剂量测量工具，并将彻底改变RT输送的进一步创新。然而，PGD尚未完全开发用于临床使用。 目的：（i）建立一个准确和可靠的PGD系统，用于进一步研究三维辐射剂量学。(ii)将该系统应用于完整患者RT过程验证和新型剂量计算算法的验证。 影响：目前的复杂性在RT交付已经超过了三维剂量测量仪器的发展，从而限制了进一步的创新在RT delivery. PGD是一个有吸引力的三维剂量学技术，由于该技术提供的剂量学信息的丰富。 建立一个强大的PGD系统是使临床接受这一工具的关键。这项工作将显著影响对目前提供的3D辐射剂量的理解，从而实现下一代RT治疗的开发。