The role of the kinetochore in age-related oocyte aneuploidy

动粒在年龄相关卵母细胞非整倍性中的作用

• 批准号: 420292
• 负责人: Fitzharris Greg
• 金额: $ 49.32万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2025-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=420292&lang=en
• 关键词: Aneuploidy; Chromosome Segregation; Infertility; Kinetochore; Oocyte

A major cause of the decline in fertility experienced by women in their 30s and 40s is a decrease in the quality of the egg. Specifically, it is known that eggs of older women are more likely to contain the wrong number of chromosomes - a state known as a

30多岁和40多岁的女性生育能力下降的一个主要原因是卵子质量下降。具体来说，众所周知，老年妇女的卵子更有可能含有错误数量的染色体-这种状态被称为“染色体异常”。