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The role of the kinetochore in age-related oocyte aneuploidy

The role of the kinetochore in age-related oocyte aneuploidy
动粒在年龄相关卵母细胞非整倍性中的作用
批准号：
420292
负责人：
Fitzharris Greg
金额：
$49.32万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-03-01 至 2025-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=420292&lang=en
关键词：
Aneuploidy Chromosome Segregation Infertility Kinetochore Oocyte

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英文摘要
A major cause of the decline in fertility experienced by women in their 30s and 40s is a decrease in the quality of the egg. Specifically, it is known that eggs of older women are more likely to contain the wrong number of chromosomes - a state known as a
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What is the underlying cause of mosaic aneuploidy in the preimplantation embryo?
What is the cause of chromosome segregation error in the mammalian preimplantation embryo?
Microtubule dynamics and age-related aneuploidy in mammalian oocytes
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