Experimental studies on ecological and genetic complexity in adaptation
适应生态和遗传复杂性的实验研究
基本信息
- 批准号:RGPIN-2019-05622
- 负责人:
- 金额:$ 4.74万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Why is the natural world so diverse? Arguably, this question remains one of the central unresolved problems in biology. My research aims to supply an answer. My aim is to provide a general, empirically-grounded theory for the origins and fate of biodiversity. I use microbial model systems to test foundational theories in evolution through experiment to do this, a technique known as experimental evolution. This approach allows me to track the emergence and fate of diversity in real time and, in combination with genome sequencing, allows me to identify the genetic changes responsible for adaptation and diversification. The research proposed here asks how well our existing models fare at explaining patterns of adaptive diversification when confronted with more ecologically and genetically complex systems than have been considered previously. ******Our short-term objectives are (1) to evaluate the impact of network topology on adaptation in metapopulations and, (2) test predictions on how the structure of fitness landscapes the mapping of genotype to fitness changes during adaptation. More specifically, we ask whether spatial structure, the network of sub-populations connected by dispersal, impacts the outcome of selection in an otherwise uniform environment. What if the environment is also spatially variable, in the sense that different patches contain different resources or stresses, a situation that should promote the evolution of diversity? How good are models of adaptation at predicting which sequence of genetic changes cause adaptation? ******This work is motivated by foundational problems, and so will contribute to basic knowledge in evolution, genetics, and ecology and training at least 17 highly qualified people, from undergraduate through to PhD, over the course of this grant. However, the lens through which much of this research happens is the management of pathogenic microbes, especially in regards to antimicrobial resistance. It has long been appreciated that many of the challenges we face in treating infectious disease have evolution at their core. This work constitutes a first step towards evaluating evolutionary theories that can inform practical solutions associated with the treatment and management of infectious disease.**
为什么自然界如此多样化?可以说,这个问题仍然是生物学中尚未解决的核心问题之一。我的研究旨在提供一个答案。我的目标是为生物多样性的起源和命运提供一个普遍的、有理论基础的理论。我使用微生物模型系统通过实验来测试进化的基础理论,这种技术被称为实验进化。这种方法使我能够在真实的时间内追踪多样性的出现和命运,并与基因组测序相结合,使我能够确定负责适应和多样化的遗传变化。这里提出的研究问题,以及我们现有的模型在解释适应性多样化的模式时,面对更多的生态和遗传复杂的系统比以前被认为是。** 我们的短期目标是(1)评估网络拓扑结构对集合种群适应的影响,(2)测试适应过程中适应度结构如何影响基因型到适应度的映射变化的预测。更具体地说,我们问是否空间结构,网络的子种群连接的分散,影响选择的结果,否则统一的环境。如果环境在空间上也是可变的,即不同的斑块包含不同的资源或压力,这种情况应该促进多样性的进化?适应模型在预测哪些遗传变化序列导致适应方面有多好?** 这项工作的动机是基础问题,因此将有助于进化,遗传学和生态学的基础知识,并在此期间培训至少17名高素质的人,从本科到博士。然而,这项研究的大部分透镜是病原微生物的管理,特别是关于抗菌素耐药性。长期以来,人们一直认识到,我们在治疗传染病方面面临的许多挑战都以进化为核心。这项工作构成了评估进化理论的第一步,这些理论可以为与传染病的治疗和管理相关的实际解决方案提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kassen, Rees其他文献
The evolution and fate of diversity under hard and soft selection
- DOI:
10.1098/rspb.2020.1111 - 发表时间:
2020-09-09 - 期刊:
- 影响因子:4.7
- 作者:
Chen, Patrick;Kassen, Rees - 通讯作者:
Kassen, Rees
Antagonistic interactions of soil pseudomonads are structured in time
- DOI:
10.1093/femsec/fix046 - 发表时间:
2017-05-01 - 期刊:
- 影响因子:4.2
- 作者:
Kraemer, Susanne A.;Soucy, Jean-Paul R.;Kassen, Rees - 通讯作者:
Kassen, Rees
Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions
- DOI:
10.1073/pnas.1721270115 - 发表时间:
2018-10-16 - 期刊:
- 影响因子:11.1
- 作者:
Schick, Alana;Kassen, Rees - 通讯作者:
Kassen, Rees
Adaptive synonymous mutations in an experimentally evolved Pseudomonas fluorescens population
- DOI:
10.1038/ncomms5076 - 发表时间:
2014-06-01 - 期刊:
- 影响因子:16.6
- 作者:
Bailey, Susan F.;Hinz, Aaron;Kassen, Rees - 通讯作者:
Kassen, Rees
Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa
- DOI:
10.1073/pnas.1307862110 - 发表时间:
2013-12-24 - 期刊:
- 影响因子:11.1
- 作者:
Dettman, Jeremy R.;Rodrigue, Nicolas;Kassen, Rees - 通讯作者:
Kassen, Rees
Kassen, Rees的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kassen, Rees', 18)}}的其他基金
Experimental studies on ecological and genetic complexity in adaptation
适应生态和遗传复杂性的实验研究
- 批准号:
RGPIN-2019-05622 - 财政年份:2022
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
Experimental studies on ecological and genetic complexity in adaptation
适应生态和遗传复杂性的实验研究
- 批准号:
RGPIN-2019-05622 - 财政年份:2021
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
COVID-19 in the urban built environment (CUBE): SARS-CoV-2 prevalence in high traffic hospital settings
城市建筑环境 (CUBE) 中的 COVID-19:人流量大的医院环境中的 SARS-CoV-2 患病率
- 批准号:
554478-2020 - 财政年份:2020
- 资助金额:
$ 4.74万 - 项目类别:
Alliance Grants
Experimental studies on ecological and genetic complexity in adaptation
适应生态和遗传复杂性的实验研究
- 批准号:
RGPIN-2019-05622 - 财政年份:2020
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
Resistance in the Urban Environment (RUE)- A stewardship initiative for managing antimicrobial resistance in Canadian cities
城市环境中的耐药性 (RUE) - 一项管理加拿大城市抗菌素耐药性的管理举措
- 批准号:
543467-2019 - 财政年份:2019
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Frontiers - Antimicrobial Resistance
Genomics of adaptation and diversification in evolving populations of microbes
微生物种群进化的适应和多样化的基因组学
- 批准号:
RGPIN-2014-04836 - 财政年份:2018
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
Genomics of adaptation and diversification in evolving populations of microbes
微生物种群进化的适应和多样化的基因组学
- 批准号:
RGPIN-2014-04836 - 财政年份:2017
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
Genomics of adaptation and diversification in evolving populations of microbes
微生物种群进化的适应和多样化的基因组学
- 批准号:
RGPIN-2014-04836 - 财政年份:2016
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
Genomics of adaptation and diversification in evolving populations of microbes
微生物种群进化的适应和多样化的基因组学
- 批准号:
462297-2014 - 财政年份:2016
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Genomics of adaptation and diversification in evolving populations of microbes
微生物种群进化的适应和多样化的基因组学
- 批准号:
RGPIN-2014-04836 - 财政年份:2015
- 资助金额:
$ 4.74万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
脂滴聚集型小胶质细胞介导的髓鞘病变促进小鼠抑郁样行为及其机制研究
- 批准号:82371528
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
星形胶质细胞介导的髓鞘吞噬参与慢性脑低灌注白质损伤的机制研究
- 批准号:82371307
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
相似海外基金
Ecological Anthropology of Mind on Ayahuasca: Prospects for Interdisciplinary Studies through the Concept of Neuroscape
死藤水的心灵生态人类学:通过神经景观概念进行跨学科研究的前景
- 批准号:
23KJ2108 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Opioid Use and Acute Suicide Risk: The Real-Time Influence of Trauma Context"
阿片类药物的使用和急性自杀风险:创伤背景的实时影响”
- 批准号:
10674342 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Bidirectional Influences Between Adolescent Social Media Use and Mental Health
青少年社交媒体使用与心理健康之间的双向影响
- 批准号:
10815392 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Sleep and circadian rhythm phenotypes and mechanisms associated with opioid use disorder treatment outcomes
睡眠和昼夜节律表型以及与阿片类药物使用障碍治疗结果相关的机制
- 批准号:
10776106 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Development of a digital therapeutic targeting anxiety sensitivity to reduce PTSD-SUD in women presenting for emergency care after sexual assault.
开发一种针对焦虑敏感性的数字疗法,以减少性侵犯后寻求紧急护理的女性的 PTSD-SUD。
- 批准号:
10449766 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Defining Cognitive Patient Reported Outcomes of Breast Cancer Survivors in the Context of Everyday Functioning and Quality of Life
在日常功能和生活质量的背景下定义乳腺癌幸存者的认知患者报告结果
- 批准号:
10658037 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
How the short-term influence of drinking consequences shapes the development of expectancies: An event-level study
饮酒后果的短期影响如何影响预期的发展:一项事件级研究
- 批准号:
10748534 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
Investigation of Sex and Gender Differences in Cardiovascular Risk in Rural Communities
农村社区心血管风险的性别和性别差异调查
- 批准号:
10608716 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别:
A Next Generation Data Infrastructure to Understand Disparities across the Life Course
下一代数据基础设施可了解整个生命周期的差异
- 批准号:
10588092 - 财政年份:2023
- 资助金额:
$ 4.74万 - 项目类别: