Analytical Chemistry

分析化学

• 批准号: 1000227987-2011
• 负责人: Li, Liang
• 金额: $ 7.29万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692626
• 关键词: Analytical; Chemistry

This research program focuses on developing analytical mass spectrometry for proteomics and metabolomics applications. Proteomics and metabolomics involve cohesive studies of all proteins (the proteome) or all metabolites (the metabolome) present in a biological system. They play an increasingly important role in biosciences, from fundamental studies of biological functions to discovery of accurate and precise disease biomarkers. Advances in both fields are being driven largely by the introduction of new analytical technologies. We propose to develop highly sensitive mass spectrometric techniques for comprehensive proteome and metabolome analysis with high specificity and throughput.

本研究计划的重点是开发蛋白质组学和代谢组学应用的分析质谱法。蛋白质组学和代谢组学涉及对生物系统中存在的所有蛋白质（蛋白质组）或所有代谢物（代谢组）的内聚性研究。它们在生物科学中发挥着越来越重要的作用，从生物功能的基础研究到发现准确和精确的疾病生物标志物。这两个领域的进步主要是由新的分析技术的引入所推动的。我们建议开发高灵敏度的质谱技术，用于蛋白质组和代谢组的综合分析，具有高特异性和高通量。