Synthetic applications of boryl carboxylates

羧酸硼酯的合成应用

• 批准号: 545140-2019
• 负责人: Yudin, Andrei
• 金额: $ 9.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693389
• 关键词: Synthetic; applications; boryl; carboxylates

In the Spring of 2019, we discovered boryl carboxylates (CBA), a new class of molecules with untapped synthetic potential. We subsequently applied for a patent to protect this composition of matter. The CBA technology quickly attracted the attention of Merck and we initiated a collaboration in order to understand the scope of potential applications of this new chemistry. As a result, we recently published a joint paper with Merck in Angewandte Chemie. We also received market assessment funding from NSERC, allowing us to retain the services of Adventus Research. Dr. G. Svoboda of Adventus has carried out a thorough market assessment study. The present I2I application considers the main messages from that report and focuses on the applications that will further de-risk our technology now that it is sufficiently mature. With the help of this report, we now have specific steps to strengthen the commercial value of the CBA technology. These include the development of a range of CBA derivatives as well as the demonstration of superior properties of these molecules in the synthesis of challenging heterocycles. Our partners (Merck, Eurofins Alphora, and MilliporeSigma) are ideally suited to help us broaden patent claims and position this technology closer to licensing.

2019年春天，我们发现了硼酸基羧酸酯（CBA），这是一种尚未开发的合成潜力的新分子。我们随后申请了一项专利来保护这种物质的组成。CBA技术很快吸引了默克的注意，我们开始合作，以了解这种新化学物质的潜在应用范围。因此，我们最近在Angewandte Chemie上与默克公司发表了一篇联合论文。我们还获得了NSERC的市场评估资金，使我们能够保留Adventus Research的服务。Adventus的G. Svoboda博士进行了全面的市场评估研究。目前的I2I应用程序考虑了该报告的主要信息，并将重点放在将进一步降低我们的技术风险的应用程序上，因为它已经足够成熟。在这份报告的帮助下，我们现在有了具体的步骤来加强CBA技术的商业价值。这包括一系列CBA衍生物的开发，以及这些分子在合成具有挑战性的杂环中的优越性质的证明。我们的合作伙伴（Merck， Eurofins Alphora和MilliporeSigma）非常适合帮助我们扩大专利申请范围，并使这项技术更接近许可。