Medicine by Design
Medicine by Design
批准号:
1000232720-2019
负责人:
Yudin, Andrei
金额:
$14.57万
依托单位:
依托单位国家:
加拿大
项目类别:
Canada Research Chairs
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-01-01 至 2021-12-31
中文摘要
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英文摘要
The proposed research program will challenge the existing principles of chemistry in order to find new therapeutics. The Yudin lab will demonstrate that taking macrocycles away from their equilibrium states is an innovative new strategy for creating bioactive structures. The emerging understanding of complex macrocycles will enable the construction of new classes of bioactive molecules. The Yudin lab will control the specificity of biomolecular interactions by targeting weakly nucleophilic residues in protein binding sites using novel boron-containing compounds. This knowledge will lead to a radically different approach to the discovery of new bioactive molecules and their subsequent translational studies.
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会议论文
Development and application of new methods for chemical synthesis
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批准号:RGPIN-2018-05732
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项目类别:Discovery Grants Program - Individual
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资助金额:$15.3万
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财政年份:2022
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负责人:Yudin, Andrei
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依托单位:
Medicine by Design
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批准号:CRC-2019-00034
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项目类别:Canada Research Chairs
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资助金额:$14.57万
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财政年份:2022
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负责人:Yudin, Andrei
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依托单位:
Development and application of new methods for chemical synthesis
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批准号:RGPIN-2018-05732
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.65万
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财政年份:2021
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负责人:Yudin, Andrei
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依托单位:
Medicine By Design
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批准号:CRC-2019-00034
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项目类别:Canada Research Chairs
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资助金额:$14.57万
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财政年份:2021
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负责人:Yudin, Andrei
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依托单位:
Development of carbon monoxide surrogates for chemical synthesis
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批准号:561229-2020
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项目类别:Alliance Grants
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资助金额:$2.48万
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财政年份:2021
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负责人:Yudin, Andrei
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依托单位:
Development of the Dominant Rotor Technology for Drug Discovery
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批准号:565585-2021
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项目类别:Alliance Grants
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资助金额:$4.77万
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财政年份:2021
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负责人:Yudin, Andrei
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依托单位:
Development and application of new methods for chemical synthesis
-
批准号:RGPIN-2018-05732
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$7.65万
-
财政年份:2020
-
负责人:Yudin, Andrei
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依托单位:
Medicine by Design
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批准号:1000232720-2019
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项目类别:Canada Research Chairs
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资助金额:$3.64万
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财政年份:2019
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负责人:Yudin, Andrei
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依托单位:
Development and application of new methods for chemical synthesis
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批准号:RGPIN-2018-05732
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.65万
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财政年份:2019
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负责人:Yudin, Andrei
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依托单位:
Synthetic applications of boryl carboxylates
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批准号:545140-2019
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项目类别:Idea to Innovation
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资助金额:$9.11万
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财政年份:2019
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负责人:Yudin, Andrei
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依托单位:
Development and application of new methods for chemical synthesis
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批准号:RGPIN-2018-05732
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.65万
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财政年份:2018
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负责人:Yudin, Andrei
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依托单位:
Carboxyboronates: powerful building blocks for chemical synthesis
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批准号:536388-2019
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项目类别:Idea to Innovation
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资助金额:$1.09万
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财政年份:2018
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负责人:Yudin, Andrei
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依托单位:
A glove box to enable transition metal-catalyzed reactions in the Yudin lab
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批准号:RTI-2018-00802
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项目类别:Research Tools and Instruments
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资助金额:$5.17万
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财政年份:2017
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负责人:Yudin, Andrei
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依托单位:
Amphoteric Molecules: from Reaction Discovery to Applications in Synthesis
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批准号:217572-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2017
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负责人:Yudin, Andrei
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依托单位:
Oxadiazole grafts in peptide macrocycles
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批准号:516247-2017
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项目类别:Idea to Innovation
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资助金额:$8.81万
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财政年份:2017
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负责人:Yudin, Andrei
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依托单位:
Amphoteric Molecules: from Reaction Discovery to Applications in Synthesis
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批准号:217572-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2016
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负责人:Yudin, Andrei
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依托单位:
Oxadiazole grafts in peptide macrocycles
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批准号:501983-2016
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项目类别:Idea to Innovation
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资助金额:$1.08万
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财政年份:2016
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负责人:Yudin, Andrei
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依托单位:
Development of a lead boron-containing ClpP inhibitor for AML therapy
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批准号:478459-2015
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项目类别:Collaborative Health Research Projects
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资助金额:$7.26万
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财政年份:2015
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负责人:Yudin, Andrei
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依托单位:
Amphoteric Molecules: from Reaction Discovery to Applications in Synthesis
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批准号:217572-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2015
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负责人:Yudin, Andrei
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依托单位:
Amphoteric Molecules: from Reaction Discovery to Applications in Synthesis
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批准号:217572-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2014
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负责人:Yudin, Andrei
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依托单位:
国内基金
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