Medicine by Design

设计医学

• 批准号: 1000232720-2019
• 负责人: Yudin, Andrei
• 金额: $ 3.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=690019
• 关键词: Medicine; Design

The proposed research program will challenge the existing principles of chemistry in order to find new therapeutics. The Yudin lab will demonstrate that taking macrocycles away from their equilibrium states is an innovative new strategy for creating bioactive structures. The emerging understanding of complex macrocycles will enable the construction of new classes of bioactive molecules. The Yudin lab will control the specificity of biomolecular interactions by targeting weakly nucleophilic residues in protein binding sites using novel boron-containing compounds. This knowledge will lead to a radically different approach to the discovery of new bioactive molecules and their subsequent translational studies.

拟议的研究计划将挑战现有的化学原理，以找到新的治疗方法。Yudin实验室将证明，将大环从其平衡状态中取出是一种创造生物活性结构的创新新策略。对复杂大环的新认识将使构建新型生物活性分子成为可能。Yudin实验室将通过使用新型含硼化合物靶向蛋白质结合位点的弱亲核残基来控制生物分子相互作用的特异性。这些知识将为发现新的生物活性分子及其随后的转化研究带来一种完全不同的方法。