Photo-Polymerization 3D Printer

光聚合3D打印机

• 批准号: RTI-2019-00293
• 负责人: MoranMirabal, Jose
• 金额: $ 9.14万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693397
• 关键词: Photo; Polymerization; 3D; Printer

3D printing is revolutionizing the way products are manufactured, with benefits including higher customization, expedited prototyping, and lower costs. In particular, the area of biofabrication is expanding rapidly, with the number of publications using 3D printing to design microenvironments for tissue engineering growing exponentially. This proposal seeks funding for a 3D printer capable of photo-polymerization of polymer, hydrogel, and nanomaterial-based bioinks into three-dimensional scaffolds for cell culture and tissue engineering. The requested 3D printer is urgently needed by the Moran-Mirabal, Bowdish, and Didar groups to perform testing and validation of novel green 3D printing bioinks which are based on functional green nanomaterials (Moran-Mirabal), to fabricate scaffolds to study age-related effects on macrophage mobility and their impact on immunity, infection and disease (Bowdish), and to develop new Organ-on-Chip systems for drug screening (Didar). Currently, there are no photo-polymerization 3D printers available at McMaster University, which severely limits our ability to carry out this research, file IP for new materials produced, and publish our findings - ultimately delaying HQP progression. The specific 3D printer requested is capable of printing up to 6 different materials in series, under temperature-controlled conditions, is capable of irradiation in UV and visible wavelengths, and has a small foot print that makes it possible to place it in a biological safety cabinet to print under a sterile environment. The 3D printer will be located in the newly renovated research wing of the Arthur N. Bourns Building at McMaster University, where it will be set up in a Biosafety Level 2 laboratory shared by faculty from the Chemistry and Chemical Biology and Chemical Engineering departments, and will be managed by a laboratory research manager. As such, the equipment will be operated as a shared instrument available to research groups interested in 3D printing scaffolds for biomedical applications. Thus, the availability of such a 3D printer will enhance the research programs not only of the applicants, but also of other groups, including the Wylie, Brook, Adronov, Selvaganapathy, Zhang, Hoare and Grandfield, by allowing them to test new materials (e.g. silicones, hydrogels, polymer bound single walled carbon nanotubes) for 3D printing or evaluate the response of cells to 3D printed scaffolds (e.g., osteoblasts for bone regeneration, mesenchymal stem cells). A delay in securing the requested 3D printer would not only prevent the applicants' research groups from expeditiously moving forward research on testing new green 3D printing bioinks, but also from 3D printing scaffolds to investigate fundamental biological questions. This will ultimately limit our ability to apply for patents, publish our results, and move student research forward to its full potential.

3D打印正在彻底改变产品的制造方式，其好处包括更高的定制化，加快原型设计和降低成本。特别是，生物制造领域正在迅速扩大，使用3D打印设计组织工程微环境的出版物数量呈指数级增长。该提案旨在为3D打印机提供资金，该打印机能够将聚合物，水凝胶和纳米材料生物墨水光聚合成用于细胞培养和组织工程的三维支架。Moran-Mirabal、Bowdish和Didar小组迫切需要所要求的3D打印机，以测试和验证基于功能性绿色纳米材料的新型绿色3D打印生物墨水（Moran-Mirabal），制造支架以研究年龄对巨噬细胞移动性的影响及其对免疫，感染和疾病的影响（Bowdish），并开发用于药物筛选的新器官芯片系统（Didar）。目前，麦克马斯特大学没有光聚合3D打印机，这严重限制了我们开展这项研究、为生产的新材料提交IP和发表我们的研究结果的能力，最终推迟了HQP的进展。所要求的特定3D打印机能够在温度控制条件下连续打印多达6种不同的材料，能够在紫外线和可见光波长下照射，并且具有小的占地面积，可以将其放置在生物安全柜中在无菌环境下打印。3D打印机将位于新装修的研究翼的亚瑟N。该实验室将设在麦克马斯特大学的Bourns大楼，由化学、化学生物学和化学工程系的教师共享一个生物安全2级实验室，并由实验室研究经理管理。因此，该设备将作为对生物医学应用的3D打印支架感兴趣的研究小组的共享工具。因此，这种3D打印机的可用性不仅将增强申请人的研究计划，而且还将增强其他小组的研究计划，包括Wylie，Brook，Adronov，Selvaganapathy，Zhang，Hoare和Grandfield，通过允许他们测试用于3D打印的新材料（例如硅酮，水凝胶，聚合物结合的单壁碳纳米管）或评估细胞对3D打印支架的响应（例如，用于骨再生的成骨细胞、间充质干细胞）。延迟获得所需的3D打印机不仅会阻止申请人的研究小组迅速推进测试新的绿色3D打印生物墨水的研究，而且还会阻止3D打印支架研究基本的生物学问题。这将最终限制我们申请专利，发表我们的成果，并推动学生研究的能力，以充分发挥其潜力。