DNA-gated stimuli-responsive nanostructures for metal sensing and smart remediation

用于金属传感和智能修复的 DNA 门控刺激响应纳米结构

• 批准号: 507070-2017
• 负责人: Liu, Juewen
• 金额: $ 14.4万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694157
• 关键词: DNA; gated; stimuli; responsive; nanostructures

Around 40% of the rivers and lakes in America are polluted, and this problem is much more serious in developing countries. In particular, water contamination by heavy metals is a growing problem with serious adverse health effects. Therefore, detection and remediation of heavy metals is a major task for analytical chemists and environmental engineers. We propose herein a biomimetic device for solving this problem. The device releases sensing or remediation chemicals only in the presence of target contaminants, while it can stably flow in water for a long time in a benign polymer capsule in the absence the target. Our approach will change the sampling-testing-remediation method to the new seeking-responding-remediation (SRR). To achieve this goal, we propose to use DNAzyme-gated polymersomes for searching contaminants and remediation. Compared to dumping chemicals into water for remediation, our approach is more targeted with a higher efficiency. This project will be performed with our collaborator in the University of Bordeaux in France through NSERC's international collaboration program. Two local Canadian companies will also be involved to guide the project to make practical impacts.

美国大约40%的河流和湖泊受到污染，这个问题在发展中国家更为严重。特别是，重金属水污染是一个日益严重的问题，对健康有严重的不利影响。因此，重金属的检测和修复是分析化学家和环境工程师的主要任务。我们在此提出一种仿生装置来解决这个问题。该装置仅在目标污染物存在时释放传感或修复化学物质，而在没有目标的情况下，它可以在良性聚合物胶囊中长时间稳定地在水中流动。我们的方法将抽样-测试-修复方法转变为新的寻找-响应-修复（SRR）方法。为了实现这一目标，我们建议使用dnazyme门控聚合体来搜索污染物和修复。与向水中倾倒化学物质进行修复相比，我们的方法更有针对性，效率更高。该项目将通过NSERC的国际合作计划与我们在法国波尔多大学的合作者一起进行。两家加拿大当地公司也将参与指导该项目产生实际影响。