Microbial Genomics

微生物基因组学

• 批准号: CRC-2019-00257
• 负责人: Whiteway, Malcolm
• 金额: $ 14.57万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695151
• 关键词: Microbial; Genomics

We will establish the transcriptional networks of the human fungal pathogen Candida albicans, and compare them with those in Saccharomyces cerevisiae. We will identify those circuits that are unique to each organism, those circuits that are common to both organisms, and finally those circuits that have rewired between the organisms and thus control distinct processes in the two fungi. While investigations of the transcriptional circuitry in the model yeast S. cerevisiae have provided fundamental insights into cell function, our work will establish which characteristics are fundamental, and which are idiosyncratic to the model under investigation.

我们将建立人类真菌病原体白色念珠菌的转录网络， 将它们与酿酒酵母中的那些进行比较。我们将识别那些电路， 每种生物体都是独一无二的，这些电路对两种生物体都是共同的，最后是那些 这些电路在生物体之间重新布线，从而控制着两个生物体中不同的过程。 真菌 在研究模式酵母S.酿酒厂有 提供了对细胞功能的基本见解，我们的工作将确定哪些特征是 基本的，并且对于所研究的模型是特殊的。