Intelligent Nanoscopy of Cellular Plasticity

细胞可塑性的智能纳米观察

• 批准号: 1000232712-2019
• 负责人: LavoieCardinal, Flavie
• 金额: $ 8.74万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695367
• 关键词: Intelligent; Nanoscopy; Cellular; Plasticity

Brain cell communication, learning, and memory depend on the activity and plasticity of synapses, submicron structures connecting neurons. Synaptic signaling and remodeling involve mechanisms taking place at the nanoscale, requiring optical nanoscopymethods to be resolved and understood. The proposed research program will combine machine learning with developments in optical nanoscopy to push the resolution and analysis of synaptic imaging. The proposed CRC is expected to drive innovation at the interface of Neuroscience, Machine Learning and Photonics, leading to discoveries on the molecular mechanisms supporting learning and memory and to novel bioimaging tools with unprecedented spatial and temporal resolution.

脑细胞的交流、学习和记忆依赖于突触的活动和可塑性，突触是连接神经元的亚微米结构。突触信号传导和重塑涉及发生在纳米尺度上的机制，需要光学纳米方法来解决和理解。拟议的研究计划将联合收割机学习与光学纳米显微镜的发展相结合，以推动突触成像的分辨率和分析。拟议的CRC有望推动神经科学、机器学习和光子学的创新，从而发现支持学习和记忆的分子机制，并开发具有前所未有的空间和时间分辨率的新型生物成像工具。