Tier II Canada Research Chair in Aquatic Toxicology and Stress Physiology

加拿大二级水生毒理学和应激生理学研究主席

• 批准号: 1000231158-2015
• 负责人: Wiseman, Steve
• 金额: $ 8.74万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695600
• 关键词: Tier; II; Canada; Research; Chair

Currently, understanding of effects of chemical stressors that threaten aquatic ecosystems is limited to those that occur during or shortly after an exposure took place. However, very little is known regarding long-term (including multigenerational) impacts that exposure to these contaminants has on the health of populations of organisms, particularly fish. By characterizing cellular mechanisms of long-term toxic responses, including alterations to the epigenome, of fishes to chemical stressors it is possible to develop tools that will significantly improve regulatory toxicity testing approaches and decrease uncertainty in chemical and environmental risk assessments for species of fishes that inhabit Canadian freshwater ecosystems.

目前，对威胁水生生态系统的化学压力源的影响的了解仅限于接触期间或接触后不久发生的影响。 然而，人们对接触这些污染物对生物种群、特别是鱼类健康的长期（包括多代）影响知之甚少。 通过表征细胞机制的长期毒性反应，包括改变表观基因组，鱼类化学应激源，它是可能的开发工具，将显着改善监管毒性测试方法和减少不确定性的化学和环境风险评估的鱼类栖息在加拿大淡水生态系统的物种。