Cellular Therapy Bioprocess Engineering

细胞治疗生物过程工程

• 批准号: CRC-2016-00058
• 负责人: Hoesli, Corinne
• 金额: $ 8.74万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695736
• 关键词: Cellular; Therapy; Bioprocess; Engineering

Cellular therapy could reduce health care costs by providing long-lasting treatments to degenerative diseases such as diabetes. The production of cells for transplantation at clinical scale will require the design of novel bioreactors. Efficient stem cell differentiation into functional cells may require signals from a 3D cell culture environment. The objective of the proposed research is to develop bioprocesses to produce therapeutic cells at clinical scale using 3D cell culture. Innovative manufacturing methods such as 3D printing of the biomaterials and cells will help overcome scale-up challenges such as producing organized 3D constructs and supplying oxygen to the cells.

细胞疗法可以通过为糖尿病等退行性疾病提供持久的治疗来降低医疗保健成本。临床规模的细胞移植生产将需要新的生物反应器的设计。有效的干细胞分化为功能细胞可能需要来自3D细胞培养环境的信号。拟议研究的目的是开发生物工艺，使用3D细胞培养以临床规模生产治疗性细胞。创新的制造方法，如生物材料和细胞的3D打印，将有助于克服规模化的挑战，如生产有组织的3D结构和为细胞提供氧气。