Functional RNA and Cellular Stress

功能性 RNA 和细胞应激

• 批准号: CRC-2016-00264
• 负责人: Audas, Timothy
• 金额: $ 8.74万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695806
• 关键词: Functional; RNA; Cellular; Stress

Cells must adapt to changing environmental conditions in order to survive. Interestingly, an emerging class of biological molecules (noncoding RNA) have recently been shown to be essential to many of these responsive pathways. Dr. Audas laboratory will study the role of noncoding RNA in the stress-induced conversion of proteins to a new type of natural protein aggregate. He intends to identify regulators, protein targets, and cellular consequences associated with this pathway, enhancing our understanding of cellular adaptability. Research outcomes will also impact the study of aggregate-based neurological diseases, generating new avenues to combat conditions affecting Canadas aging population.

细胞必须适应不断变化的环境条件才能生存。有趣的是，一种新兴的生物分子（非编码RNA）最近被证明对许多这些反应途径至关重要。Audas博士的实验室将研究非编码RNA在应激诱导蛋白质转化为新型天然蛋白质聚集体中的作用。他打算确定与此途径相关的调节因子，蛋白质靶点和细胞后果，增强我们对细胞适应性的理解。研究成果还将影响基于聚集的神经系统疾病的研究，为应对影响加拿大人口老龄化的条件开辟新的途径。