Chemical Biology

化学生物学

• 批准号: 1000230754-2014
• 负责人: Shuhendler, Adam
• 金额: $ 2.19万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695915
• 关键词: Chemical; Biology

Minute changes in the molecular processes driving our cells signal the onset of disease, or its reversal through treatment, long before outward signs or symptoms. The non-invasive detection of these changes is possible through MRI or PET, however has not yet been realized due to a lack of available tracer chemistry capable of amplifying these molecular signals. To this end, a toolbox of tracer chemistry platforms engineered to amplify these minute molecular changes and applicable to a broad range of molecular targets for both MRI and PET imaging will be developed, with the potential for improving disease diagnosis and therapy.

驱动我们细胞的分子过程中的微小变化预示着疾病的发生，或通过治疗使疾病逆转，这远远早于外在的迹象或症状。通过MRI或PET对这些变化进行无创检测是可能的，但由于缺乏能够放大这些分子信号的可用示踪化学，尚未实现。为此，将开发一个工具箱的示踪化学平台，用于放大这些微小的分子变化，并适用于MRI和PET成像的广泛分子靶标，具有改善疾病诊断和治疗的潜力。