Chemical Biology

化学生物学

• 批准号: CRC-2019-00004
• 负责人: Shuhendler, Adam
• 金额: $ 7.29万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730566
• 关键词: Chemical; Biology

Dr. Shuhendler's research vision remains the imaging of fundamental biochemistry with high spatial and temporal resolution in live subjects. Through the development of chemical probes that can report on biomolecular activities deep in the body, he will be able to more completely understand how these biomolecules drive injury (e.g. concussion) and can modulate therapeutic success (e.g. the drug resistance phenotype of cancer). On the one hand, his research outcomes will enhance our understanding of key biomolecular effectors of life through enabling probe technologies. On the other hand, his work can also provide clinically relevant agents to expand diagnostic imaging capabilities.

Shuhendler博士的研究愿景仍然是在活体中以高空间和时间分辨率成像基础生物化学。通过开发可以报告体内深处生物分子活动的化学探针，他将能够更全面地了解这些生物分子如何驱动损伤（例如脑震荡）并调节治疗成功（例如癌症的耐药性表型）。一方面，他的研究成果将通过使能探针技术增强我们对生命的关键生物分子效应器的理解。另一方面，他的工作也可以提供临床相关的药物，以扩大诊断成像能力。