Cognitive Neuroscience

认知神经科学

• 批准号: CRC-2019-00037
• 负责人: Barense, Morgan
• 金额: $ 7.29万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695977
• 关键词: Cognitive; Neuroscience

Early detection of Alzheimers disease (AD) is essential, as treatments will be effective only before irreversible brain damage has occurred. Dr. Barense will apply recent neuroscience discoveries to develop sensitive markers for preclinical AD. Unlike other methods requiring a lumbar puncture or exposure to radiation, her measures are non-invasive. Thus, they can be administered repeatedly to asymptomatic individuals, enabling screening more of the population. Second, she will provide an effective, inexpensive, and non-invasive Digital Memory Augmentation device that externally mimics AD-compromised brain function. With her improved early detection measures, she will administer this intervention when it will be most effective.

阿尔茨海默病（AD）的早期检测是必不可少的，因为治疗只有在不可逆的脑损伤发生之前才有效。Barense博士将应用最新的神经科学发现来开发临床前AD的敏感标志物。与其他需要腰椎穿刺或暴露于辐射的方法不同，她的措施是非侵入性的。因此，它们可以重复施用给无症状个体，从而能够筛查更多的人群。其次，她将提供一种有效、廉价、非侵入性的数字记忆增强设备，该设备可以在外部模仿AD受损的大脑功能。随着她改进的早期检测措施，她将在最有效的时候进行干预。