Metabolic Systems Engineering

代谢系统工程

• 批准号: CRC-2019-00227
• 负责人: Mahadevan, Radhakrishnan
• 金额: $ 14.57万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696081
• 关键词: Metabolic; Systems; Engineering

Advances in DNA sequencing, synthesis and assembly of DNA parts have revolutionized the way biological systems are characterized and engineered leading to an exciting opportunity to apply them for addressing global challenges. In parallel, systems approaches to modeling biology have enabled the integration of large-scale genomic data sets to understand the metabolic networks that drives cellular functions and to manipulate these metabolic systems for practical applications in energy, environment and medicine. Specifically, we will develop novel methods for analyzing and engineering metabolic systems and apply them for the production of bio-nylon and probiotics for the treatment of inflammatory bowel disease.

DNA测序、DNA部分合成和组装的进步彻底改变了生物系统的特征和设计方式，为应用它们应对全球挑战提供了令人兴奋的机会。与此同时，建模生物学的系统方法使大规模基因组数据集的集成能够理解驱动细胞功能的代谢网络，并操纵这些代谢系统用于能源，环境和医学的实际应用。具体来说，我们将开发分析和工程代谢系统的新方法，并将其应用于治疗炎症性肠病的生物尼龙和益生菌的生产。