Semi-Permanent Tattoos - Transforming a Canadian Start-Up Company's Product Through Fundamental Chemistry

半永久纹身 - 通过基础化学改造加拿大初创公司的产品

基本信息

  • 批准号:
    531774-2018
  • 负责人:
  • 金额:
    $ 14.57万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Research and Development Grants
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

Dyes which are either sourced directly or derived from naturally-occurring products are of growing interest in the cosmetics industry. Sourcing chemical dyes or their close precursors from natural products can significantly reduce the environmental impact of manufacture by reducing the number of derivatization and purification steps. The industrial partner, Inkbox Ink, currently uses genipin, a dye precursor derived primarily from extracts of the gardenia fruit, in their semi-permanent tattoo technologies. The general mechanism of action involves the reaction of genipin with primary amines, in this case amino acids in the skin. The mechanism by which a colourless fruit extract becomes a brilliant blue dye is poorly understood, with numerous reports providing contradictory hypotheses. The rare ability of genipin to rapidly form non-permanent skin dyes suggests a number of potential applications. In order to develop new target dyes and facilitate new dermal technologies, the mechanism of action must be better understood. This collaborative research program endeavours to elucidate the mechanism and discover new molecules through systematic synthetic modifications and analytical experiments. The knowledge gained from these studies will be applied to the development of new dyes and skin-binding technologies for Inkbox to commercialize, allowing for rapid growth of a Canadian start-up company.
直接来源或来自天然产品的染料在化妆品行业引起了越来越大的兴趣。从天然产品中采购化学染料或其接近的前体,可通过减少衍生化和提纯步骤的数量,大大减少生产对环境的影响。工业合作伙伴Inkbox Ink目前在他们的半永久性纹身技术中使用genipin,这是一种染料前体,主要从栀子果的提取物中提取。一般的作用机制包括京尼平与伯胺的反应,在这种情况下,伯胺是皮肤中的氨基酸。无色水果提取物变成明亮的蓝色染料的机制还不太清楚,许多报告提供了相互矛盾的假说。京尼平快速形成非永久性皮肤染料的罕见能力表明了许多潜在的应用。为了开发新的靶标染料和促进新的真皮技术的发展,必须更好地了解其作用机理。这一合作研究项目致力于通过系统的合成修饰和分析实验来阐明机理和发现新的分子。从这些研究中获得的知识将用于开发新的染料和Inkbox的皮肤粘合技术,使其商业化,从而使一家加拿大初创公司快速成长。

项目成果

期刊论文数量(0)
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Caputo, Christopher其他文献

Caputo, Christopher的其他文献

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{{ truncateString('Caputo, Christopher', 18)}}的其他基金

Main-Group Catalysis and Sustainable Chemistry
主族催化和可持续化学
  • 批准号:
    CRC-2021-00020
  • 财政年份:
    2022
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Canada Research Chairs
Metal-Free Materials for Catalysis
用于催化的无金属材料
  • 批准号:
    CRC-2016-00050
  • 财政年份:
    2022
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Canada Research Chairs
Developing New Approaches for Main-Group Molecules and Materials in Catalysis
开发催化主族分子和材料的新方法
  • 批准号:
    RGPIN-2018-05827
  • 财政年份:
    2022
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Discovery Grants Program - Individual
Metal-Free Materials For Catalysis
用于催化的无金属材料
  • 批准号:
    CRC-2016-00050
  • 财政年份:
    2021
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Canada Research Chairs
Developing New Approaches for Main-Group Molecules and Materials in Catalysis
开发催化主族分子和材料的新方法
  • 批准号:
    RGPIN-2018-05827
  • 财政年份:
    2021
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Discovery Grants Program - Individual
Metal-Free Materials for Catalysis
用于催化的无金属材料
  • 批准号:
    CRC-2016-00050
  • 财政年份:
    2020
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Canada Research Chairs
Developing New Approaches for Main-Group Molecules and Materials in Catalysis
开发催化主族分子和材料的新方法
  • 批准号:
    RGPIN-2018-05827
  • 财政年份:
    2020
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Discovery Grants Program - Individual
Metal-Free Materials for Catalysis
用于催化的无金属材料
  • 批准号:
    CRC-2016-00050
  • 财政年份:
    2019
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Canada Research Chairs
Developing New Approaches for Main-Group Molecules and Materials in Catalysis
开发催化主族分子和材料的新方法
  • 批准号:
    RGPIN-2018-05827
  • 财政年份:
    2019
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Discovery Grants Program - Individual
Semi-Permanent Tattoos - Transforming a Canadian Start-Up Company's Product Through Fundamental Chemistry
半永久纹身 - 通过基础化学改造加拿大初创公司的产品
  • 批准号:
    531774-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 14.57万
  • 项目类别:
    Collaborative Research and Development Grants

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