Design of probiotic bacteria to promote digestive and metabolic health

肠道微生物区系在增强肠道屏障方面起着关键作用。 来自人体肠道的反应。上皮屏障完整性丧失，也称为渗漏 肠道可导致低度炎症，并与许多疾病的发生有关 人类慢性疾病，来自炎症性肠病(IBD)和代谢 综合症/2型糖尿病到帕金森氏病、慢性肾脏疾病，甚至某些 癌症。由于它对这些慢性病的深远影响，有一个未得到满足的 需要制定新的战略来抵消经济衰退带来的有害系统性后果 肠子漏了。在这个项目中，我们将设计益生菌，以提高 微生物产物，称为MDP，针对一种名为NOD2的宿主蛋白质。我们已经展示了 激活NOD2可以对抗肠道渗漏，促进肠壁愈合 受伤后。同时，NOD2的触发也可以改善代谢健康。 因此，这些益生菌可用于保护和治疗肠道相关疾病患者。 问题以及代谢性疾病，如2型糖尿病。

The gut microbiota plays a key role in strengthening the gut barrier by stimulating protective responses from the human intestine. Loss of epithelial barrier integrity, also known as a leaky gut can lead to low-grade inflammation and is linked to the development of a number of chronic diseases in humans, from inflammatory bowel disease (IBD) and metabolic syndrome/type 2 diabetes to Parkinsons disease, chronic kidney disease and even certain cancers. Because of its far-reaching impact on these chronic diseases, there is an unmet need to develop new strategies to counteract the detrimental systemic consequences of a leaky gut. In this project, we will design probiotic bacteria that will increase the levels of a microbial product, called MDP, which targets a host protein called NOD2. We have shown that NOD2 activation can fight against a leaky gut and promote healing of the intestinal lining after injury. At the same time, NOD2 triggering can also improve metabolic health. Consequently, these probiotics could be used to protect and treat individuals with gut-related problems as well as metabolic diseases, such as type 2 diabetes.