Alternative gel hand sanitizers and non-alcohol-based long-term sanitizers for surfaces and skin with anti-viral activity for COVID-19 response

用于应对 COVID-19 的具有抗病毒活性的替代凝胶洗手液和非酒精类长期消毒剂，适用于表面和皮肤

• 批准号: 550385-2020
• 负责人: Trant, John
• 金额: $ 3.64万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=701008
• 关键词: Alternative; gel; hand; sanitizers; non

While we await vaccines or effective treatments for COVID-19, hand and surface sanitizers are going to remain essential tools in the emergency crisis today, and in the return-to work reality. COVID-19 is a global pandemic. This not only means that it threatens all of humanity; it also means that it has stressed our globalized supply chains, meaning that the raw ingredients for hand sanitizers have become difficult to obtain. The WHO formula is an excellent emergency solution, but the liquid formulation does not remain on the hands long enough to properly disinfect, and it is also harsh on the skin when used frequently for a prolonged period. A gentler formulation is required, and gels that remain on the hands for at least 20 seconds are preferred. The standard ingredients used for gelling sanitizers, however, are not available because of both the supply and demand pressures. Furthermore, any alcohol hand sanitizer, gel or liquid, is only truly effective on otherwise clean hands: the presence of dirt or grease render it far less effective. In Windsor-Essex, the Trant Lab at the University of Windsor has come together a group of for-profit companies to develop made-in-Canada solutions. We have already disbursed tens of thousands of litres of sanitizer to emergency workers and the public. This grant supports our transition to designing 1) new gelling formulations using readily available ingredients; 2) water-free, oil-based formulations that will be effective even on dirty hands to ensure that essential workers can remain safe while doing their work out in the community; and 3) long lasting and safe liquid disinfectants that will ensure that commonly touched surfaces remain COVID-free with minimal maintenance. Our sanitizers are being screened against bacteria and both a rat coronavirus and SARS-CoV-2. The industrial team, represented by Wolfhead Distillery and Peak Processing on this grant, have been assisting with regulatory compliance, scale-up to thousand litre batches, packaging, distribution, and possible commercialization of these formulations to make sure that our new effective recipes will get into the hands of the public as quickly as feasible.

在我们等待 COVID-19 疫苗或有效治疗方法的同时，洗手液和表面消毒剂仍将是当今紧急危机和重返工作岗位的重要工具。 COVID-19 是一种全球流行病。这不仅意味着它威胁到全人类；而且意味着它威胁到了全人类。这也意味着它给我们的全球化供应链带来了压力，意味着洗手液的原材料变得难以获得。世界卫生组织配方是一种很好的紧急解决方案，但液体配方在手上停留的时间不足以进行适当消毒，而且长时间频繁使用也会对皮肤造成伤害。需要更温和的配方，并且最好能在手上保留至少 20 秒的凝胶。然而，由于供应和需求压力，用于凝胶消毒剂的标准成分无法获得。此外，任何酒精洗手液，无论是凝胶还是液体，都只对清洁的手真正有效：污垢或油脂的存在使其效果大大降低。 在温莎-埃塞克斯郡，温莎大学的特兰特实验室聚集了一群营利性公司来开发加拿大制造的解决方案。我们已经向急救人员和公众分发了数万升消毒剂。这笔赠款支持我们过渡到设计：1）使用现成成分的新胶凝配方； 2) 无水、油基配方，即使在脏手上也能发挥作用，确保重要工作人员在社区工作时保持安全； 3) 持久且安全的液体消毒剂，可确保经常接触的表面无需维护即可保持无新冠病毒。我们正在对消毒剂进行细菌、大鼠冠状病毒和 SARS-CoV-2 筛查。以 Wolfhead Distillery 和 Peak Process 为代表的工业团队一直在协助这些配方的监管合规性、批量扩大到千升、包装、分销和可能的商业化，以确保我们新的有效配方将尽快进入公众手中。