Harnessing the Power of Cannabinoids to Reverse Cannabis-induced Toxicosis in Pets.

加拿大大麻合法化，加上人们对大麻态度的改变，导致宠物故意和无意接触大麻的情况有所增加。动物接触大麻的症状通常包括抑郁、共济失调、散瞳、异常惊吓、听觉过敏、心动过缓、体温过低、尿失禁，甚至死亡。这项建议旨在解决宠物与大麻相关的毒性(通常是由于存在β-9-四氢大麻酚[THC])的问题，并测试新的治疗途径，以减少故意和意外暴露的中毒相关伤害。目前的治疗选择包括监测和去污，因此强调了新的药理治疗的必要性。这一合作的行业赞助商/合作伙伴是Avicanna Inc.，这是一家生物制药公司，自成立以来一直致力于大麻类药物产品的开发。与Khokhar博士合作，他在行为药理学方面有着广泛的记录，这项合作旨在更深入地了解大麻引起宠物中毒的神经基础，以及大麻衍生化合物和配方在帮助治疗宠物大麻引起的中毒方面的潜在效用。这一系列实验的目的是首先在大鼠模型中建立大麻中毒的行为和神经相关性，然后测试大麻二醇和四氢大麻碱(这两种药物都可以抵消THC的影响)单独和联合使用对THC诱导的中毒的影响。这项研究的具体目标如下： 目的1：通过食用和蒸气给药途径，确定急性大剂量THC暴露的行为和神经相关性。 目的2：确定大麻二醇或丙型肝炎病毒单独或联合治疗是否能降低急性大剂量THC中毒的行为和神经相关性。 这些研究的结果将是有影响的，因为他们将确定一种潜在的新的治疗途径，以减少THC诱导的宠物中毒，以及建立THC诱导的中毒的神经关联。

The legalization of cannabis in Canada, combined with the changing attitudes towards cannabis, have resulted in increases in both intentional and unintentional exposures to cannabis in pets. Signs that an animal has been exposed to cannabis generally include depression, ataxia, mydriasis, abnormal startle, acoustic hypersensitivity, bradycardia, hypothermia, urinary incontinence, and although rare, even death.This proposal aims to tackle the issue of cannabis-associated toxicity (usually due to the presence of delta-9-tetrahydrocannabinol [THC]) in pets and to test novel therapeutic avenues toward reducing toxicosis-related harms, from both intentional and accidental exposure. Current treatment options include monitoring and decontamination, therefore underscoring the need for novel pharmacological treatments. The industry sponsor/partner for this collaboration is Avicanna Inc., a biopharmaceutical company solely devoted to the development of cannabinoid-based medicinal products since its inception. In partnership with Dr. Khokhar, with his extensive track-record in behavioural pharmacology, this collaboration aims to provide a deeper understanding of the neural basis of cannabis-induced toxicosis in pets as well as the potential utility of cannabis-derived compounds and formulations for aiding the treatment of cannabis-induced toxicosis in pets. The goal of this series of experiments is to first establish the behavioural and neural correlates of cannabis-toxicosis in a rat model, and then test the effects of cannabidiol and tetrahydrocannabivarin (both agents can counteract the effect of THC), both alone and in combination on THC-induced toxicosis. The specific aims for this study are as follows: Aim 1: To determine the behavioural and neural correlates of acute high-dose THC exposure via edible and vapour routes of administration. Aim 2: To determine whether cannabidiol or THCV treatment, either alone or in combination, reduce the magnitude of the behavioural and neural correlates of acute high-dose THC toxicosis. The findings from these studies will be impactful since they will identify a potentially novel therapeutic avenue for reducing THC-induced toxicosis in pets, as well as establishing the neural correlates of THC-induced toxicosis.