Harnessing the Power of Cannabinoids to Reverse Cannabis-induced Toxicosis in Pets.

利用大麻素的力量逆转大麻引起的宠物中毒。

• 批准号: 549529-2019
• 负责人: Khokhar, Jibran
• 金额: $ 5.1万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722571
• 关键词: Harnessing; Power; Cannabinoids; Reverse; Cannabis

The legalization of cannabis in Canada, combined with the changing attitudes towards cannabis, have resulted in increases in both intentional and unintentional exposures to cannabis in pets. Signs that an animal has been exposed to cannabis generally include depression, ataxia, mydriasis, abnormal startle, acoustic hypersensitivity, bradycardia, hypothermia, urinary incontinence, and although rare, even death.This proposal aims to tackle the issue of cannabis-associated toxicity (usually due to the presence of delta-9-tetrahydrocannabinol [THC]) in pets and to test novel therapeutic avenues toward reducing toxicosis-related harms, from both intentional and accidental exposure. Current treatment options include monitoring and decontamination, therefore underscoring the need for novel pharmacological treatments. The industry sponsor/partner for this collaboration is Avicanna Inc., a biopharmaceutical company solely devoted to the development of cannabinoid-based medicinal products since its inception. In partnership with Dr. Khokhar, with his extensive track-record in behavioural pharmacology, this collaboration aims to provide a deeper understanding of the neural basis of cannabis-induced toxicosis in pets as well as the potential utility of cannabis-derived compounds and formulations for aiding the treatment of cannabis-induced toxicosis in pets. The goal of this series of experiments is to first establish the behavioural and neural correlates of cannabis-toxicosis in a rat model, and then test the effects of cannabidiol and tetrahydrocannabivarin (both agents can counteract the effect of THC), both alone and in combination on THC-induced toxicosis. The specific aims for this study are as follows:Aim 1: To determine the behavioural and neural correlates of acute high-dose THC exposure via edible and vapour routes of administration.Aim 2: To determine whether cannabidiol or THCV treatment, either alone or in combination, reduce the magnitude of the behavioural and neural correlates of acute high-dose THC toxicosis.The findings from these studies will be impactful since they will identify a potentially novel therapeutic avenue for reducing THC-induced toxicosis in pets, as well as establishing the neural correlates of THC-induced toxicosis.

加拿大大麻合法化，加上对大麻态度的改变，导致宠物有意和无意接触大麻的情况增加。 动物暴露于大麻的症状通常包括抑郁、共济失调、瞳孔放大、异常惊吓、听觉过敏、心动过缓、体温过低、尿失禁，甚至死亡（尽管罕见）。（通常是由于δ-9-四氢大麻酚[THC]的存在），并测试新的治疗途径，以减少中毒相关的伤害，无论是有意还是无意的接触目前的治疗方案包括监测和去污，因此强调需要新的药物治疗。此次合作的行业赞助商/合作伙伴是Avicanna Inc.，一家生物制药公司，自成立以来一直致力于开发基于大麻素的医药产品。Khokhar博士在行为药理学方面有着广泛的记录，此次合作旨在更深入地了解大麻诱导的宠物中毒的神经基础，以及大麻衍生化合物和制剂的潜在效用，以帮助治疗大麻诱导的宠物中毒。这一系列实验的目的是首先在大鼠模型中建立大麻中毒的行为和神经相关性，然后测试大麻二酚和四氢大麻酚（两种药物都可以抵消THC的作用）单独和组合对THC诱导的中毒的影响。这项研究的具体目的如下：目的1：确定通过食用和蒸汽途径急性接触高剂量四氢大麻酚的行为和神经相关性。为了确定大麻二酚或THCV治疗是否单独或联合，降低急性高血压的行为和神经相关性的程度，来自这些研究的发现将是有影响力的，因为它们将确定用于减少宠物中THC诱导的中毒以及建立THC诱导的中毒的神经相关性的潜在的新治疗途径。