Antiviral polymers as surface coating materials for curbing the spread of COVID-19

抗病毒聚合物作为表面涂层材料用于遏制 COVID-19 的传播

• 批准号: 553988-2020
• 负责人: Xi, Li
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=704490
• 关键词: Antiviral; polymers; surface; coating; materials

The COVID-19 pandemic has brought enormous human and economic costs. Limiting its transmission rate within the population is the most critical task in its control, as reducing the total number of infections at any given time can prevent the healthcare system from being overburdened. Although the coronavirus is airborne, it can survive on certain types of common surfaces for days, leading to a significant risk of surface transmission. Our goal is to develop a technology of coating materials surfaces with antiviral polymers, which quickly inactivates viruses after contact. This coating can be applied to furniture, flooring, and other general surfaces in public spaces to reduce the risk of contamination and transmission. It will also enable the development of a new generation of personal protective equipment (PPE) with built-in antiviral properties. The proposed work targets a central challenge in the formulation design of this technology. It will combine computer simulation with experiments to understand, at the molecular level, how certain types of polymers dismantle coronavirus particles. Meanwhile, consideration will also be given to evaluate their suitability for coating on substrate surfaces in terms of interfacial and mechanical properties. The direct outcome of this project will be a clear set of molecular guidelines on the ideal polymer chemical structure for such an application, which is essential for our continued formulation development of this coating material.

2019冠状病毒病大流行带来了巨大的人力和经济代价。限制其在人群中的传播率是控制其最关键的任务，因为在任何给定时间减少感染总数可以防止卫生保健系统负担过重。虽然冠状病毒是通过空气传播的，但它可以在某些类型的常见表面上存活数天，从而导致表面传播的重大风险。我们的目标是开发一种用抗病毒聚合物涂覆材料表面的技术，这种技术可以在接触病毒后迅速灭活病毒。这种涂料可以应用于家具、地板和其他公共场所的一般表面，以减少污染和传播的风险。它还将促进具有内置抗病毒特性的新一代个人防护装备（PPE）的开发。提出的工作目标是该技术配方设计中的一个核心挑战。它将把计算机模拟与实验结合起来，在分子水平上了解某些类型的聚合物如何分解冠状病毒颗粒。同时，还将考虑从界面和力学性能方面评估其在基材表面涂层的适用性。该项目的直接成果将是一套明确的分子指南，用于这种应用的理想聚合物化学结构，这对我们继续开发这种涂层材料的配方至关重要。