Antiviral polymers as surface coating materials for curbing the spread of COVID-19

抗病毒聚合物作为表面涂层材料用于遏制 COVID-19 的传播

• 批准号: 553988-2020
• 负责人: Xi, Li
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=704490
• 关键词: Antiviral; polymers; surface; coating; materials

The COVID-19 pandemic has brought enormous human and economic costs. Limiting its transmission rate within the population is the most critical task in its control, as reducing the total number of infections at any given time can prevent the healthcare system from being overburdened. Although the coronavirus is airborne, it can survive on certain types of common surfaces for days, leading to a significant risk of surface transmission. Our goal is to develop a technology of coating materials surfaces with antiviral polymers, which quickly inactivates viruses after contact. This coating can be applied to furniture, flooring, and other general surfaces in public spaces to reduce the risk of contamination and transmission. It will also enable the development of a new generation of personal protective equipment (PPE) with built-in antiviral properties. The proposed work targets a central challenge in the formulation design of this technology. It will combine computer simulation with experiments to understand, at the molecular level, how certain types of polymers dismantle coronavirus particles. Meanwhile, consideration will also be given to evaluate their suitability for coating on substrate surfaces in terms of interfacial and mechanical properties. The direct outcome of this project will be a clear set of molecular guidelines on the ideal polymer chemical structure for such an application, which is essential for our continued formulation development of this coating material.

共同的19个大流行带来了巨大的人类和经济成本。限制人口内的传输率是其控制中最关键的任务，因为在任何给定时间减少感染总数可以防止医疗保健系统的负担过重。尽管冠状病毒是空降的，但它可以在某些类型的常见表面上存活几天，从而导致表面传播的显着风险。我们的目标是用抗病毒聚合物开发涂层材料表面的技术，该技术在接触后迅速失活病毒。该涂层可用于公共空间中的家具，地板和其他一般表面，以降低污染和传播的风险。它还将使新一代的个人防护设备（PPE）开发具有内置抗病毒特性。拟议的工作针对该技术制定设计的核心挑战。它将将计算机模拟与实验结合在一起，以了解某些类型的聚合物如何拆卸冠状病毒颗粒。同时，还将考虑根据界面和机械性能评估其对底物表面涂层的适用性。该项目的直接结果将是有关这种应用的理想聚合物化学结构的明确分子准则，这对于我们持续制定该涂层材料的制定至关重要。