Quick Evaluation of Advanced Personal Protective Equipment (PPE) During COVID-19 by Using Nanostructured Sensing Assay

使用纳米结构传感检测快速评估 COVID-19 期间的高级个人防护装备 (PPE)

• 批准号: 554560-2020
• 负责人: Zhang, Jin
• 金额: $ 3.64万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705543
• 关键词: Quick; Evaluation; Advanced; Personal; Protective

Due to the extremely contagious nature yet unknown pathology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans, it is vital to have effective Personal Protective Equipment (PPE) used by people, particularly, healthcare workers. Grafoid Inc., a Canadian company, is developing cost-effective PPE by using its unique graphene-based nanofibers. The major goal of Grafoid Inc is to achieve a massive production of graphene-based nanofibers with good performance in the prevention of the spread of SARS-CoV-2 particles through the integration of nanofibers with filtration materials used for face masks. To improve the quality of Gradoid's nanofibers, and quickly evaluate the performance of the advanced and cost-effective PPE, Dr. Jin Zhang from Western University will collaborate Grafoid to achieve the following goals. Aim-1: Modify the surface of Grafoid's nanofibers incorporating filtration materials used for the face mask to efficiently trap/block aerosol (fine mist) droplets. Aim-2: Based on our established graphene-based biosensing assay, a biosensor platform for quickly detecting SARS-CoV-2, causing COVID-19, will be developed for rapid evaluation of Grafoid's nanofiber-based medical face mask or PPE to fight against COVID-19. Aim-3: Establish a protocol of quick evaluating the advanced PPE made with Grafoid's nanofibers in terms of ultra gas permeability, strong capability for blocking pathogens including viral particles, and good biocompatibility. Two PhD students will be involved in this proposed project. With the successful results of this proposed project, Grafoid will quickly provide the advanced and cost-effective PPE which is vital to offer the solution of the global shortage of PPE during COVID-19, particularly, medical face mask.

由于严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）在人类感染的传染性极强，但病理学尚不清楚，因此人们（特别是医护人员）使用有效的个人防护装备（PPE）至关重要。Grafoid Inc.，一家加拿大公司，正在通过使用其独特的石墨烯基纳米纤维开发具有成本效益的PPE。Grafoid公司的主要目标是实现石墨烯基纳米纤维的大规模生产，通过将纳米纤维与用于口罩的过滤材料相结合，在预防SARS-CoV-2颗粒传播方面具有良好的性能。为了提高Gradoid纳米纤维的质量，并快速评估先进且具有成本效益的PPE的性能，西部大学的Jin Zhang博士将与Grafoid合作实现以下目标。目标一：修改Grafoid的纳米纤维表面，将过滤材料用于面罩，以有效地捕获/阻止气溶胶（细雾）液滴。目标二：基于我们已建立的石墨烯生物传感检测方法，将开发一种快速检测引起COVID-19的SARS-CoV-2的生物传感器平台，用于快速评估Grafoid的纳米纤维医用口罩或PPE，以对抗COVID-19。目标三：建立一个快速评估方案，评估由Grafoid纳米纤维制成的先进PPE的超透气性、强大的阻隔病原体（包括病毒颗粒）能力和良好的生物相容性。 两名博士生将参与这个拟议的项目。随着此建议项目的成功结果，Grafoid将迅速提供先进及具成本效益的个人防护装备，这对解决COVID-19期间全球个人防护装备短缺（尤其是医用口罩）的问题至关重要。