Ageing and the muscle stem cell niche

衰老和肌肉干细胞生态位

• 批准号: FT110100373
• 负责人: A/Prof Robyn Meech
• 金额: $ 49.74万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-05-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT110100373
• 关键词: Ageing; muscle; stem; cell; niche

Adult stem cells are critical for repair and maintenance of tissues and ageing tissues show reduced stem cell function. This project will focus on how ageing leads to disruption of communication between muscle stem cells and their niche. The project aims to identify new therapeutic targets for age-related muscle wasting and reduced mobility in the elderly.

成人干细胞对组织的修复和维持至关重要，老化的组织显示干细胞功能减弱。该项目将重点研究衰老如何导致肌肉干细胞和它们的利基之间的通讯中断。该项目旨在为老年人与年龄相关的肌肉萎缩和活动减少确定新的治疗目标。