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Ribosome impairments, translation and bone marrow failure

Ribosome impairments, translation and bone marrow failure
核糖体损伤、翻译和骨髓衰竭
批准号：
444490
负责人：
Dror Yigal
金额：
$65.65万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-04-01 至 2026-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=444490&lang=en
关键词：
Bone Marrow Failure Dnajc21 Hematopoiesis Ribosome Biogenesis Shwachman-Diamond Syndrome Transcription Translation

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中文摘要
翻译
骨髓（BM）通过复杂的多步骤过程每天产生数百万个血细胞。白色血细胞抵抗感染，血小板防止出血，红细胞提供氧气;所有这些都是维持生命的关键。血液形成减少是一个常见的问题，
英文摘要
Bone marrow (BM) makes millions of blood cells per day via a complex multistep process. White blood cells fight infections, platelets prevent bleeding and red cells deliver oxygen; all are crucial to sustain life. Reduced blood formation is a common probl
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Dissecting the hematopoietic hierarchy and function using inherited human disease models of hematopoietic stem cell/progenitor loss
Dissecting early and progressive leukemogenic impairments in the hematopoietic hierarchy and function using pre-leukemic inherited bone marrow failure syndromes as human disease models
Deciphering the pathobiology of Shwachman Diamond syndrome hematopoietic failure using induced pluripotent stem cells
Inherited bone marrow failure syndromes: from genomic discoveries to biology
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