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Dissecting early and progressive leukemogenic impairments in the hematopoietic hierarchy and function using pre-leukemic inherited bone marrow failure syndromes as human disease models

Dissecting early and progressive leukemogenic impairments in the hematopoietic hierarchy and function using pre-leukemic inherited bone marrow failure syndromes as human disease models
使用白血病前遗传性骨髓衰竭综合征作为人类疾病模型，剖析造血层次和功能中的早期和进行性白血病损伤
批准号：
357473
负责人：
Dror Yigal
金额：
$73.29万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2021-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=357473&lang=en
关键词：
Acute Myeloid Leukemia Aplastic Anemia Clonal Architecture Deep Immunophenotyping Genetics Hematopoiesis Inherited Marrow Failure Syndromes Myelodysplastic Syndrome

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Acute myeloid leukemia (AML) is a blood cancer with a bleak outlook despite treatment with intensive chemotherapy and bone marrow (BM) transplant. Tools for early detection and prevention are desperately needed. Yet, it is unknown how AML evolves because
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