Targeting Ultrasound Therapy to the Spine

针对脊柱的超声治疗

基本信息

  • 批准号:
    RGPIN-2016-06336
  • 负责人:
  • 金额:
    $ 1.97万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

Ultrasound (US) can elicit a range of therapeutic effects on tissues, including stimulating cell proliferation, facilitating drug delivery and focally ablating tissue. Because US is non-ionizing and can be focused at depth in the body without damage to the intervening tissues, it is particularly well suited for targets in, or in close proximity to, sensitive structures, and has great potential for use in the spine. US-mediated drug, cell or gene delivery to the spinal cord could revolutionize the treatment of spinal cord injury and disease. Targeted to the intervertebral disc or facet joints, US could play an important role in the management of back pain. A major limitation to the clinical realization of these treatments is the need to focus the US through the complex bony structures of the posterior spinal elements. Bone is highly attenuating and aberrating to sound, and treating through bony structures is only possible through the use of US transducer arrays that can correct the beam distortions caused by the bone, and which operate within an optimal frequency range. In the brain this technology is in-hand and has been investigated clinically. However, the spinal geometry is more complex than the skull. Acoustic windows such as the interlaminar spaces will facilitate access to some targets. In other regions, non-normal incidence angles will reflect and refract the US, and the narrow spinal canal may give rise to standing waves. Thus, the development of extracorporeal US transducer arrays that are capable of focusing in the spinal setting is necessary to advance this technology. The overall goal of this research program is to use numerical simulations and bench-top measurements to test the hypothesis that extracorporeal ultrasound can be focused non-invasively to targets in the spinal cord and spinal column at therapeutically relevant exposures. The specific aims to achieve this are: 1. To develop acoustic simulation models of the human spine at cervical, thoracic and lumbar levels using computed tomography (CT)-derived geometry. 2. To experimentally validate the numerical models through comparison with acoustic and thermal measurements in cadaveric spine segments. 3. To use the validated models to assess the ability of ultrasound to safely target different structures in the spine. 4. To determine, through numerical optimization, the ultrasound transducer geometry that maximizes the treatment envelope. 5. To fabricate and characterize a prototype transducer for targeting the spine. This research will lay the groundwork for clinical-scale investigations in the spine using therapeutic US, and has immense potential to be a disruptive technology in this arena. By eliminating a major obstacle to clinical translation, establishing the technical feasibility of this approach will also encourage further research to identify new clinical applications in the spine.
超声(US)可以对组织产生一系列治疗作用,包括刺激细胞增殖、促进药物输送和局部消融组织。由于US是非电离的,并且可以在不损伤介入组织的情况下聚焦在身体的深度,因此它特别适合于敏感结构中或接近敏感结构的目标,并且在脊柱中具有很大的使用潜力。超声介导的药物、细胞或基因传递到脊髓可能会彻底改变脊髓损伤和疾病的治疗。超声针对椎间盘或小关节,可以在背痛的治疗中发挥重要作用。 这些治疗的临床实现的主要限制是需要通过脊柱后部元件的复杂骨结构聚焦US。骨对声音具有高度衰减和畸变,并且只有通过使用能够校正由骨引起的波束失真并且在最佳频率范围内操作的US换能器阵列,才有可能通过骨结构进行治疗。在大脑中,这种技术是在手,并已在临床上进行了研究。然而,脊柱的几何形状比头骨更复杂。声窗,如层间空间,将有助于接近某些目标。在其他区域,非垂直入射角将反射和反射US,并且狭窄的椎管可能引起驻波。因此,有必要开发能够在脊柱环境中聚焦的体外US换能器阵列,以推进该技术。 本研究项目的总体目标是使用数值模拟和台式测量来测试体外超声可以在治疗相关暴露下无创聚焦到脊髓和脊柱中的目标的假设。实现这一目标的具体目标是: 1.使用计算机断层扫描(CT)衍生几何学,开发颈椎、胸椎和腰椎水平的人体脊柱声学模拟模型。 2.通过与尸体脊柱节段中的声学和热测量进行比较,实验验证数值模型。 3.使用经确认的模型评估超声安全靶向脊柱不同结构的能力。 4.通过数值优化确定使治疗包络最大化的超声换能器几何形状。 5.旨在制造和表征用于靶向脊柱的原型换能器。 这项研究将为使用治疗性US在脊柱中进行临床规模的研究奠定基础,并且具有成为这一竞技场中的颠覆性技术的巨大潜力。通过消除临床转化的主要障碍,确立这种方法的技术可行性也将鼓励进一步研究,以确定脊柱的新临床应用。

项目成果

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OReilly, Meaghan其他文献

OReilly, Meaghan的其他文献

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{{ truncateString('OReilly, Meaghan', 18)}}的其他基金

Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2021
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual
Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2019
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual
Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2018
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual
Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2017
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual
Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2016
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual

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Targeting Ultrasound Therapy to the Spine
针对脊柱的超声治疗
  • 批准号:
    RGPIN-2016-06336
  • 财政年份:
    2021
  • 资助金额:
    $ 1.97万
  • 项目类别:
    Discovery Grants Program - Individual
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