Ultrasound Stimulated Chondrogenic Stem Cell Therapy for Osteoarthritis
超声刺激软骨干细胞治疗骨关节炎
基本信息
- 批准号:10701506
- 负责人:
- 金额:$ 31.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-22 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-Dimensional3D ultrasoundAdipose tissueAffectAftercareAnimal ModelArthritisArticular Range of MotionBiological AssayBiomechanicsCartilageCellsClinicalClinical ResearchClinical TrialsDefectDegenerative DisorderDegenerative polyarthritisDirect CostsDiseaseDisease ProgressionEncapsulatedEnvironmentExposure toFacilities and Administrative CostsFatigueFlow CytometryFutureGaitHip region structureHistologicHistologyHumanHyaluronic AcidHydrogelsHypoxiaImplantIn VitroJointsKneeMeniscus structure of jointMesenchymalMesenchymal Stem CellsModalityModelingMolecularMusculoskeletal SystemNatural regenerationNude RatsOperative Surgical ProceduresOutcomePainPatientsPersonsPhasePhysiologic pulseProliferatingRattusReplacement ArthroplastyResearchSamplingSmall Business Innovation Research GrantSourceSpecimenStimulusSymptomsSynovial FluidTestingTimeTissuesUltrasonic TherapyViscosityadipose derived stem cellarticular cartilagecartilage regenerationcartilage repaircostdesigndisabilityeffective therapyefficacy evaluationexperimental studyfunctional improvementgenetic analysisimproved mobilityin vivoknee replacement arthroplastynovel therapeuticsosteoarthritis painpain reductionregenerativerepairedresponsestem cell therapystem cellssymptom managementthree dimensional cell culturetissue regenerationtreatment groupultrasound
项目摘要
Abstract
Osteoarthritis (OA) is the most common degenerative disease in the musculoskeletal system. While it can affect any
joint, hip, and knee, OA carries an enormous burden of pain and reduced mobility. Despite decades of research, there
are currently no clinically effective treatments that can repair damaged cartilage or halt the progression of this disease.
However, recent advances in tissue regeneration show that stem cell therapy has the potential to repair damaged
cartilage. In addition, ultrasound (US) stimulation has also shown encouraging results in treating OA symptoms. This is
because cartilage is a mechanotransductive tissue that responds anabolic to biomechanical stimuli. Therefore, we
hypothesize that the combined use of stem cells and US will have a synergistic response in treating OA. This hypothesis
will be tested in three specific aims. In the first aim, we compare the chondrogenic differentiation of two different stem
cell sources, mesenchymal and adipose, using in vitro 3D culture and US exposure time period. In the second aim, we will
implant the optimal US-enhanced chondrogenic cells from Aim 1 in human articular cartilage defects, ex vivo, and
compare pulsed to continuous ultrasound. Finally, in the third aim, we will test the optimized US-enhanced
chondrogenic hyaluronic hydrogel encapsulated cell in vivo using an OA rat model. These studies will allow us to
develop a new ultrasound-induced chondrogenic stem cell therapy that can repair cartilage tissue, regress the OA
progression, and reduce osteoarthritic pain significantly.
摘要
项目成果
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