Beyond estimation: broadening the dynamic treatment regime literature

超越估计：扩大动态治疗方案文献

• 批准号: RGPIN-2017-04221
• 负责人: Wallace, Michael
• 金额: $ 1.38万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710447
• 关键词: Beyond; estimation; broadening; dynamic; treatment

Dynamic treatment regimes are a statistical way of deciding what decisions to make. They originate in medicine, where tailoring treatments to individual patients - rather than prescribing the same drug to everyone with a particular disease - can lead to improved health. This is because the best treatment for two different patients may not be the same, such as older patients faring better than younger ones using a certain medication, or patients having varying degrees of tolerance to side-effects. By analyzing data we can find the best dynamic treatment regime for each patient: a set of rules that tell us the best treatment to prescribe at any given time based on an individual patient's characteristics. What's more, the potential of dynamic treatment regimes is not limited to medicine. In any situation where a sequence of decisions is made (such as steps in an engineering process, or decisions over time in a scientific experiment), we can analyze data to work out the best actions to take. Within statistics, dynamic treatment regimes have received considerable study over the last decade, seeing the development of many different approaches to finding the best sequence of decisions in any given setting. This research program will expand this area of statistics into new, exciting directions. It focuses on solving problems that, though important, remain largely unaddressed in this relatively young field. For example, when analyzing data, specialists take a broad guess at how different decisions might affect an outcome, before statistical analyses 'fill in the blanks'. So far, relatively little work has been done in checking how good these broad guesses are. Another problem is that in the real world data are often measured with error (think how precisely you might measure a piece of wood, or the accuracy of your car's fuel gauge); this can badly undermine our results, so work needs to be done to take this problem into account. This research will have impact within statistics as well as the wider research community. For the former, it will address important theoretical problems while forming new links between different areas of statistics (which in turn will advance the field as a whole). Beyond statistics, though seemingly specialized, this work has wide-reaching potential in decision-making processes. By rapidly expanding the contexts where dynamic treatment regimes can be applied, researchers from different specialties will find more opportunities to use - and benefit from - these methods. Finally, this program will see the training of numerous highly qualified individuals, who will go on to provide important contributions of their own, be it to statistics, the wider scientific community, industry, or Canada as a whole.

动态治疗方案是一种决定做出什么决定的统计方法。它们起源于医学，为个体患者量身定制治疗-而不是为患有特定疾病的每个人开同样的药物-可以改善健康。这是因为对两个不同病人的最佳治疗方法未必相同，例如使用某种药物时，年长病人的情况较年轻病人为佳，又或病人对副作用的耐受程度各有不同。通过分析数据，我们可以为每个患者找到最佳的动态治疗方案：一组规则，告诉我们在任何给定时间根据个体患者的特征开出最佳治疗方案。更重要的是，动态治疗方案的潜力不仅限于医学。在任何情况下，如果要做出一系列决策（例如工程过程中的步骤，或科学实验中的决策），我们都可以分析数据以制定最佳行动。 在统计学中，动态治疗制度在过去十年中得到了大量研究，看到了许多不同方法的发展，以找到任何特定环境中的最佳决策顺序。这项研究计划将扩大这一领域的统计到新的，令人兴奋的方向。它专注于解决问题，虽然重要，但在这个相对年轻的领域中基本上尚未解决。例如，在分析数据时，专家们会在统计分析“填补空白”之前，对不同的决策可能会如何影响结果进行广泛的猜测。到目前为止，在检查这些广泛的猜测有多好方面所做的工作相对较少。另一个问题是，在真实的世界中，数据的测量经常会有误差（想想你测量一块木头的精确度，或者你汽车燃油表的准确度）;这会严重破坏我们的结果，所以需要做一些工作来考虑这个问题。 这项研究将在统计学以及更广泛的研究界产生影响。对于前者，它将解决重要的理论问题，同时在不同的统计领域之间建立新的联系（这反过来将推动整个领域）。除了统计之外，这项工作虽然看似专门化，但在决策过程中具有广泛的潜力。通过快速扩展动态治疗方案的应用范围，来自不同专业的研究人员将找到更多使用这些方法并从中受益的机会。最后，该计划将看到许多高素质的个人，谁将继续提供自己的重要贡献的培训，无论是统计，更广泛的科学界，工业，或加拿大作为一个整体。