Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
基本信息
- 批准号:RGPIN-2017-04487
- 负责人:
- 金额:$ 3.5万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The focus of my research program is to discover how land plants are related to each other, and to use this information to understand major life-history shifts across the plant tree of life. The first component of our proposed work uses genome-focused approaches to reconstruct phylogenetic relationships for a broad range of plant groups. We will apply this knowledge to understand what happens in plant lineages that have lost the ability to photosynthesize (the process by which plants use energy from the sun to produce glucose from carbon dioxide and water). The non-photosynthetic plants of interest, called mycoheterotrophs, have evolved convergently around 50 times in different plant groups. They rely on soil fungal partners for their fixed carbon and other nutrients. We propose to examine how all three plant genomes of mycoheterotrophs are affected by this major nutritional shift. We will perform detailed studies of the two organellar genomes found in plant cells, the plastid and mitochondrion. The plastid genome is expected to be especially prone to modification and degradation in response to the evolution of obligate heterotrophy, as the plastid's primary role (as the chloroplast of green plants) is to perform photosynthesis. We will test and refine models for how this genome degrades following the loss of photosynthesis, by sequencing plastid genomes from multiple mycoheterotrophic plant groups, allowing us to screen for convergent patterns of gene loss and retention. The effect of photosynthesis loss on the plant mitochondrial genome is much less well understand, and will also be addressed by looking for convergent patterns of change in this organellar genome. We will also use focused transcriptome studies of the nuclear genome to look at shifts in gene expression in nuclear-encoded organellar genes. Finally, we will employ tests to detect instances of relaxed selection in lineages undergoing major life-history shifts, such as the origin of mycoheterotrophy. For example, the timing of shifts in selection intensity may predate a noticeable life-history change, if the environment is already acting on subsets of genes prior to the major shift. We will address this by looking at the effects of multiple types of life-history shifts, including mycoheterotrophy, in addition to convergent losses of a major plastid protein complex (NAD(P)H dehydrogenase) in submerged aquatic plants (land plants that returned to the water) and carnivorous plants. The proposed work includes new training opportunities in genomic methods for students, including undergraduate researchers.
我的研究项目的重点是发现陆地植物是如何相互关联的,并利用这些信息来了解植物生命树的主要生命史转变。我们提出的工作的第一个组成部分使用基因组为重点的方法来重建系统发育关系的广泛的植物群体。我们将应用这些知识来了解失去光合作用能力的植物谱系中发生了什么(植物利用太阳能从二氧化碳和水产生葡萄糖的过程)。感兴趣的非光合植物,称为真菌异养生物,在不同的植物群中进化了大约50次。它们依靠土壤真菌伙伴来获得固定碳和其他养分。我们建议研究所有三种植物基因组的真菌异养菌是如何影响这一重大的营养转变。我们将对植物细胞中发现的两种细胞器基因组进行详细的研究,质体和质体。预计质体基因组特别容易响应专性异养的进化而发生修饰和降解,因为质体的主要作用(如绿色植物的叶绿体)是进行光合作用。我们将测试和完善模型,这个基因组如何降解后光合作用的损失,通过测序质体基因组从多个mycoheterotrophic植物群体,使我们能够筛选基因丢失和保留的收敛模式。光合作用丧失对植物线粒体基因组的影响还不太清楚,也将通过寻找该细胞器基因组中的收敛变化模式来解决。我们还将使用核基因组的聚焦转录组研究来观察核编码的细胞器基因中基因表达的变化。最后,我们将采用测试来检测放松选择的情况下,经历重大的生活史转变,如起源的mycoheterotrophy的血统。例如,选择强度变化的时间可能早于明显的生活史变化,如果环境在主要变化之前已经作用于基因的子集。我们将通过研究多种类型的生活史转变的影响来解决这个问题,包括真菌异养,以及沉水植物(陆地植物返回水中)和食肉植物中主要质体蛋白复合物(NAD(P)H脱氢酶)的趋同损失。拟议的工作包括为学生,包括本科生研究人员提供基因组方法的新培训机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Graham, Sean其他文献
Fluence field optimization for noise and dose objectives in CT
- DOI:
10.1118/1.3574885 - 发表时间:
2011-07-01 - 期刊:
- 影响因子:3.8
- 作者:
Bartolac, Steven;Graham, Sean;Jaffray, David - 通讯作者:
Jaffray, David
The potential of resistance inducers and synthetic fungicide combinations for management of foliar diseases of nursery stock
- DOI:
10.1016/j.cropro.2021.105636 - 发表时间:
2021-04-09 - 期刊:
- 影响因子:2.8
- 作者:
Percival, Glynn C.;Graham, Sean - 通讯作者:
Graham, Sean
myShoes - the future of experiential dementia training?
- DOI:
10.1108/jmhtep-10-2015-0048 - 发表时间:
2016-01-01 - 期刊:
- 影响因子:1
- 作者:
Adefila, Arinola;Graham, Sean;Ball, Steven - 通讯作者:
Ball, Steven
Graham, Sean的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Graham, Sean', 18)}}的其他基金
Genomic approachs to studying plant evolution, function and phylogeny
研究植物进化、功能和系统发育的基因组方法
- 批准号:
RGPIN-2022-05098 - 财政年份:2022
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2021
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2019
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2018
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2017
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Genomic and phylogenetic approaches for investigating plant biodiversity and evolution
研究植物生物多样性和进化的基因组和系统发育方法
- 批准号:
217133-2012 - 财政年份:2016
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Genomic and phylogenetic approaches for investigating plant biodiversity and evolution
研究植物生物多样性和进化的基因组和系统发育方法
- 批准号:
217133-2012 - 财政年份:2015
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Genomic and phylogenetic approaches for investigating plant biodiversity and evolution
研究植物生物多样性和进化的基因组和系统发育方法
- 批准号:
217133-2012 - 财政年份:2014
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Self-Bound Bose-Einstein Condensates
自束缚玻色-爱因斯坦凝聚态
- 批准号:
465401-2014 - 财政年份:2014
- 资助金额:
$ 3.5万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Genomic and phylogenetic approaches for investigating plant biodiversity and evolution
研究植物生物多样性和进化的基因组和系统发育方法
- 批准号:
429383-2012 - 财政年份:2014
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
相似国自然基金
果蝇转座元件和piRNA之间的基因组冲突及对杂交不育的影响
- 批准号:91431101
- 批准年份:2014
- 资助金额:120.0 万元
- 项目类别:重大研究计划
优化基因组策略搜寻中国藏族内耳畸形的致病基因及其致聋机制研究
- 批准号:31071099
- 批准年份:2010
- 资助金额:40.0 万元
- 项目类别:面上项目
电离辐射诱发间充质干细胞基因组非稳定性的研究
- 批准号:31070759
- 批准年份:2010
- 资助金额:34.0 万元
- 项目类别:面上项目
辣椒胞质雄性不育恢复性主效基因精密图谱分析
- 批准号:30800752
- 批准年份:2008
- 资助金额:21.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2021
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.
整合理论、基因组学和比较方法,打破理解基因组结构和性染色体进化的障碍。
- 批准号:
10028965 - 财政年份:2020
- 资助金额:
$ 3.5万 - 项目类别:
Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.
整合理论、基因组学和比较方法,打破理解基因组结构和性染色体进化的障碍。
- 批准号:
10643867 - 财政年份:2020
- 资助金额:
$ 3.5万 - 项目类别:
Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.
整合理论、基因组学和比较方法,打破理解基因组结构和性染色体进化的障碍。
- 批准号:
10424490 - 财政年份:2020
- 资助金额:
$ 3.5万 - 项目类别:
Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.
整合理论、基因组学和比较方法,打破理解基因组结构和性染色体进化的障碍。
- 批准号:
10207691 - 财政年份:2020
- 资助金额:
$ 3.5万 - 项目类别:
Comparative genomic and phylogenetic approaches for investigating plant diversity and evolution
研究植物多样性和进化的比较基因组和系统发育方法
- 批准号:
RGPIN-2017-04487 - 财政年份:2019
- 资助金额:
$ 3.5万 - 项目类别:
Discovery Grants Program - Individual
Computational approaches for comparative regulatory genomics to decipher long-range gene regulation
比较调控基因组学的计算方法来破译远程基因调控
- 批准号:
10208923 - 财政年份:2018
- 资助金额:
$ 3.5万 - 项目类别: