Microsensing System for Real-time Pathogen Detection

用于实时病原体检测的微传感系统

• 批准号: RGPIN-2017-03763
• 负责人: Lai, Yongjun
• 金额: $ 1.82万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710522
• 关键词: Microsensing; System; Real; time; Pathogen

According to a recent report the market for biosensors in applications such as point of care, home diagnostics, research labs, biodefense, environmental monitoring, food industry, is projected to be US$22.68 billion and at an estimated compound annual growth rate (CAGR) of 10.0% from 2014 to 2020. Increasing demands for rapid detection, onsite accessibility, and operation simplicity etc., are driving the development of new biosensing technologies. Microelectromechanical systems (MEMS) involve complex micro- and nano-scale integration of mechanical elements, sensors, actuators, and electronics by advanced fabrication technology. MEMS sensors have demonstrated superior capability of detecting minuscule mass. However, their high intrinsic sensitivity is challenged in real-time detections which are often conducted at atmospheric pressure and room temperature with liquid samples. Damping, pathogen collection, and signal detection/processing are the three barriers that need to be overcome to achieve real-time pathogen detection with MEMS sensors. In this research, novel MEMS sensors will be developed which will integrate piezoelectric actuation, surface acoustic wave (SAW) sorting, electrokinetic pathogen collection and capture, and a piezoelectric sensing or optical position sensing element. Through piezoelectric actuation elements, enough excitation energy can be applied to the sensors to overcome damping from testing sample solutions. SAW elements will be used to sort and concentrate pathogens, which will be collected and captured by the sensor via electrokinetic elements; Piezoelectric sensing or optical position sensitive devices (PSD) convert the sensors' dynamic response to the electrical signal, and allow the miniaturization. The novelty of the proposed MEMS sensors stems from the novel design and integration of multi-functional elements. The proposed research is an excellent platform to provide unique interdisciplinary training opportunities to graduate and undergraduate students. Over the next five years, the proposed research program will train 11 HQP including 4 PhD, 2 Master and 5 undergraduate students (summer students) for professional careers in high-tech engineering. Upon graduation, the trainees will be well-trained and knowledgeable experts in leading-edge micromanufacturing technology, Micro-biosensing technology, and micromechatronics engineering, and be ready for professional careers in industry and academia. The novel technology derived from this study can be widely employed for water quality monitoring, environmental biosafety enhancement, clinical diagnostics, bio-contamination identification etc., and will support relevant Canadian industry, e.g. Trojan Technologies, Veolia Water technology, Maple food Inc. Abbott, NXTSENS etc., to enhance their international competitiveness.

根据最近的一份报告，生物传感器在医疗保健、家庭诊断、研究实验室、生物防御、环境监测、食品工业等应用中的市场规模预计为226.8亿美元，从2014年到2020年的复合年增长率(CAGR)估计为10.0%。对快速检测、现场可访问性和操作简单性等方面的日益增长的需求正在推动新的生物传感技术的发展。 微电子机械系统(MEMS)是指利用先进的制造技术，将机械元件、传感器、执行器和电子器件进行微纳尺度的复杂集成。MEMS传感器在检测微小质量方面表现出了优异的能力。然而，它们的高本征灵敏度在实时检测中受到了挑战，这种检测通常是在常压和室温下对液体样品进行的。要实现MEMS传感器对病原体的实时检测，需要克服衰减、病原体采集和信号检测/处理这三个障碍。 在这项研究中，将开发新型的MEMS传感器，它将集成压电驱动、声表面波(SAW)分选、电动病原体收集和捕获以及压电传感或光学位置传感元件。通过压电驱动元件，可以将足够的激励能量施加到传感器上，以克服测试样品溶液的阻尼。SAW元件将用于对病原体进行分类和浓缩，传感器将通过电动元件收集和捕获病原体；压电传感或光学位置敏感器件(PSD)将传感器对电信号的动态响应转换为微型化。所提出的MEMS传感器的新颖性来自于多功能元件的新颖设计和集成。 拟议的研究是一个极好的平台，为研究生和本科生提供独特的跨学科培训机会。在未来五年内，拟议的研究计划将培养11名HQP，包括4名博士、2名硕士和5名本科生(暑期学生)，用于高科技工程的专业生涯。学员毕业后将成为在前沿微制造技术、微生物传感技术和微机电工程方面训练有素和知识渊博的专家，并为进入工业界和学术界的专业生涯做好准备。 这项研究衍生的新技术可广泛应用于水质监测、环境生物安全增强、临床诊断、生物污染物识别等领域，并将支持加拿大相关产业，如特洛伊科技、威立雅水务技术、枫叶食品公司、雅培、NXTSENS等，以提高其国际竞争力。