Advancing dynamic MEMS for in-situ biosensing

推进原位生物传感的动态 MEMS

• 批准号: 327081-2012
• 负责人: Lai, Yongjun
• 金额: $ 1.46万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571918
• 关键词: Advancing; dynamic; MEMS; situ; biosensing

Water-borne contamination (e.g. E. Coli) and food-borne contamination (e.g. Listeria) have given rise to an increasing demand for fast, reliable and cost-effective biosensors that can detect in-situ bacteria for the purpose of screening for disease, food safety inspection, and water quality monitoring. Conventional biomolecular detection technology has limitations and can't provide real-time testing in the field and at the point of care. As a result, there is an urgent need for a new technique that will be capable of real-time in-situ screening or monitoring for the presence of bacteria. MEMS (microelectromechanical systems) dynamic sensors are great candidates for minuscule mass detections and have found relevant applications in air or vacuum. However, MEMS dynamic sensors for applications in aqueous solutions are not yet well investigated. In this study MEMS dynamic sensors for live bacteria detection in aqueous solution will be studied and fundamentals of MEMS dynamic sensors, working aqueous environment will be explored. In addition, a deeper understanding of amplifying sensing signals by actively manipulating the bioanalytes will be investigated. The outcome of this research will not only result in improved health screening and better food safety, but will also place Canadian researchers and diagnostics technology companies at a strategic advantage for the development of these technologies. Furthermore, the proposed work will enable a novel approach focused on applying micro sensors in a broader range of applications, particularly for a real-time in-situ sensing of bioanalytes at ultra-low concentration. The proposed work includes the design, simulation, micromachining, packaging and testing of novel microscopic biosensors. Due to the unique interdisciplinary nature of the project, it includes mechanical, electrical, chemical engineering and physics, etc. Exposed to state-of-the-art design and simulation tools, fabrication and testing facilities, the trainees involved in this project will accumulate extensive analytical and experimental skills that will meet the increasing industrial and academic demands for micro/nano technology.

水传播污染（例如E.大肠杆菌（Coli）和食源性污染（例如李斯特菌（Listeria））引起了对快速、可靠和具有成本效益的生物传感器的日益增长的需求，该生物传感器可以检测原位细菌，用于疾病筛查、食品安全检查和水质监测。 传统的生物分子检测技术具有局限性，无法在现场和护理点提供实时检测。 因此，迫切需要一种能够实时原位筛选或监测细菌存在的新技术。 MEMS（微机电系统）动态传感器是微小质量检测的理想选择，并已在空气或真空中找到相关应用。然而，MEMS动态传感器在水溶液中的应用还没有得到很好的研究。本研究将探讨微机电系统动态感测器在水溶液中的应用，并探讨微机电系统动态感测器的基本原理、工作环境。此外，将研究通过主动操纵生物分析物来放大传感信号的更深入理解。这项研究的成果不仅将改善健康筛查和食品安全，而且还将使加拿大研究人员和诊断技术公司在开发这些技术方面处于战略优势。此外，所提出的工作将使一种新的方法，专注于在更广泛的应用中应用微传感器，特别是在超低浓度的生物分析物的实时原位传感。 建议的工作包括设计，模拟，微加工，封装和测试的新型微观生物传感器。由于该项目独特的跨学科性质，它包括机械、电气、化学工程和物理等。参与该项目的学员将接触最先进的设计和模拟工具、制造和测试设施，积累广泛的分析和实验技能，以满足工业和学术界对微/纳米技术日益增长的需求。