Rapid and ultrasensitive (bio)chemical detection with dendritic metallic nanoparticle structures

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The need for analytical technologies that provide rapid, quantitative, and ultrasensitive detection of chemical compounds in environmental or biological samples is globally on the rise. Raman spectroscopy, with its inherent biochemical specificity, simplicity in sample preparation and portability potential is an ideal method for in situ sample testing. One particular mode of Raman spectroscopy, termed “Surface-enhanced Raman scattering” (SERS), has emerged as a powerful analytical technique for applications in point-of-care diagnostics, detection of explosives, and harmful chemicals in food and water. SERS enables detection of molecules in contact with metallic nanostructures (1 to 100 nm), known as "hotspots", and can enhance the Raman signal of a target molecule up to 14 orders of magnitude.