Registration of Endoscopic Optical Information to Volumetric Imaging

内窥镜光学信息与体积成像的配准

• 批准号: RGPIN-2019-04759
• 负责人: Weersink, Robert
• 金额: $ 2.84万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=714883
• 关键词: Registration; Endoscopic; Optical; Information; Volumetric

Background: In medical practice, radiological and endosopic/optical imaging each supply complimentary and unique clinical information. Radiological imaging measures bulk tissue properties supplied in 3D spatial coordinates that accurately match those of the physical subject. However, it has insufficient contrast and resolution to identify clinically important mucosal information. Endoscopic optical imaging is invaluable for disease diagnosis, and monitoring treatment response of mucosal anatomy. However, such 2D optical images are spatially disconnected from the subject's 3D spatial coordinates/anatomy or their spatial relationship may be inferred indirectly by the viewer. From the clinical perspective, what is missing is the anatomical context and relationship of the endoscopy information with respect to the bulk tissue properties supplied by the radiological imaging. For many diseases in hollow organs such as the head and neck, gastrointestinal tract and lung, spatially accurate mapping of endoscopic imaging to bulk radiological imaging would improve diagnosis and treatment. Attempts to achieve such registration using tracking technologies and computer vision are inaccurate or difficult to implement in hollow organs. True 3D endoscopic imaging for hollow organs remains elusive; especially a version registered to standard radiological imaging that includes subsurface information. Our long-term vision is the development of a “full” 3D optical/endoscopic imaging package registered to standard radiological imaging. The system will be designed specifically for hollow organs using endoscopic imaging, with the goal of registering both 2D optical images of the surface topology and subsurface information derived from optical tomography to 3D anatomical imaging. The primary objective in this proposal is the technology development and testing of the core technologies, not clinical verification and deployment. We propose two general objectives to achieve this goal. The first objective is 3D endoscopy in which 2D endoscopic images are mapped onto a 3D surface of the object in view. Our goal is registration error between the surface topology and CT images 80%. On their own, the proposed objectives are unique, offering significant advances in each field: any form of 3D endoscopy for hollow organs will have substantial clinical benefit while increased clinical adoption of optical tomography requires the improved reconstruction accuracy proposed here. Integration of optical and radiological imaging will substantially improve disease diagnosis and treatment planning in hollow organs.

背景：在医学实践中，放射学和内窥镜/光学成像各自提供互补和独特的临床信息。放射成像测量以3D空间坐标提供的大块组织属性，精确匹配物理对象的属性。然而，它的对比度和分辨率不足以识别临床上重要的粘膜信息。内镜下光学成像对疾病诊断和监测粘膜解剖治疗反应具有重要意义。然而，这样的二维光学图像在空间上与主体的三维空间坐标/解剖结构是脱节的，或者它们的空间关系可能由观看者间接推断出来。