Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury Management

项目摘要/摘要 吸入性损伤是平民人口发病和死亡的重要原因。它通常是由 吸入烟雾或有毒气体，如一氧化碳、氰化氢、二氧化氮等。 支气管镜检查目前被用作吸入性损伤评估的标准方法。然而，它未能做到 提供粘膜下和功能组织信息，这两个信息对于正确的分类和选择都是必不可少的 进行适当的治疗。物理科学公司与北卡罗来纳大学教堂山分校合作， 提出开发一种新型内窥镜多功能呼吸道光学相干层析成像仪 组织损伤管理，将为临床医生提供有关组织形态和 损伤组织的功能变化。该仪器将补充支气管镜检查的定性结果 定量的粘膜下形态和功能信息，如纤毛活动和顺应性， 将能够对吸入暴露进行更有效的筛查、分类和治疗指导。 第一阶段计划的目标是证明拟议的呼吸道技术的可行性。 吸入性损伤评估，而在第二阶段将提议开发一种先进的临床仪器 并在人类急性吸入性损伤患者身上进行了初步试验。

Project Summary/Abstract Inhalation injury is an important cause of morbidity and mortality in the civilian population. It is usually caused by the inhalation of smoke or toxic gases, such as carbon monoxide, hydrogen cyanide, nitrogen dioxide, etc. Bronchoscopy is currently used as a standard approach for inhalation injury assessment. However, it fails to provide submucosal and functional tissue information, both of which are essential for proper triage and selection of appropriate therapy. Physical Sciences Inc., in collaboration with the University of North Carolina, Chapel Hill, proposes to develop a novel Endoscopic Multifunctional Optical Coherence Tomography instrument for Airway Tissue Injury Management that will provide clinicians with real-time feedback regarding the morphological and functional changes of the injured tissue. This instrument will complement qualitative bronchoscopic findings with quantitative submucosal morphological and functional information, such as ciliary activity and compliance, which will enable more efficient screening, triage, and therapeutic guidance of inhalation exposures. The goal of the Phase I program is to demonstrate the feasibility of the proposed technology for airway inhalation injury assessment, while in Phase II an advanced clinical instrument will be proposed to be developed and preliminarily tested on human patients of acute inhalation injury.