Photonics of Surfaces and Interfaces

表面和界面光子学

• 批准号: RGPIN-2019-05908
• 负责人: Mittler, Silvia
• 金额: $ 2.62万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=715006
• 关键词: Photonics; Surfaces; Interfaces

INTRODUCTION My research program is focused on the study and design of novel surfaces and interfaces using waveguides and plasmonics, which exhibit a thin film of light (called evanescent field) directly located at a surface or an interface to an adjacent object. In nano-plasmonics, metal nanoparticles (NPs) show a very strong film of light and a strong absorption band, allowing colorimetric or transmission devices for high sensitivity chemical sensors. The light films are also applied in surface microscopy. Scattering/fluorescence evanescent microscopy is used to study surfaces and interfaces, coatings, bacteria film formation and single cell-substratum interaction. My group is known world-wide for its highly sophisticated, interdisciplinary research and achievements through many scientific contributions in form of high impact publications, outstanding conference contributions and well-trained students with their own success stories. My research will center around three key themes critical for fundamental surface/interface science. OBJECTIVES AND APPROACHES 1. AuNPs for (Bio)-Sensing Platforms: two new lean and facile sensor schemes in multiplexing form integrating our newly developed AuNP-strip-loading technology for channel waveguide definition as well as the recently discovered and described (by us) line-width narrowing effect of the localized surface plasmon resonance will be developed. Health and environmental issues of AuNPs will be addressed by developing a recycling method for the AuNP sensor platforms (safe disposal after use). 2. (Bio)-Interfaces, Coatings and Collagen Films: involves the fabrication of highly oriented collagen films on implants for an enhanced biocompatibility, avoiding the host rejection, and the mimicking of anisotropic tissue with its physical characteristics. A novel Langmuir-Blodgett (LB) trough design with a circularly closing barrier will be established. In addition, a technology to fabricate free-standing oriented collagen films will be developed. With these free-standing films, possibly multilayered, new cornea implant strategies should be enabled. 3. Waveguide Evanescent Field Microscopy: a dynamically operating evanescent microscope and novel high optical quality waveguide chips fabricated from polymers (stiff and flexible) will be developed to allow studying and enhancing the adhesion-quality of cells to technical surfaces (important for medical implants). Also envisioned is the scientific groundwork for developing a miniaturized infant pace maker. SIGNIFICANCE AND IMPACT Besides the excellent training of HQP in a multidisciplinary setting on state-of-the-art technology and Rs high tech Rs economic wealth and to Canadian life.

引言 我的研究计划专注于利用波导和等离子激元来研究和设计新颖的表面和界面，这种表面和界面展示了一种直接位于邻近物体的表面或界面上的薄膜光(称为消失场)。在纳米等离子体中，金属纳米颗粒(NPs)表现出非常强的光膜和强吸收带，可以用于高灵敏度化学传感器的比色或传输设备。这种薄膜还可应用于表面显微镜。散射/荧光消逝显微镜被用来研究表面和界面、涂层、细菌膜的形成和单细胞-基质的相互作用。我的团队以其高度复杂的跨学科研究和成就而闻名世界，通过许多科学贡献，如高影响力的出版物、杰出的会议贡献和训练有素的学生，以及他们自己的成功故事。我的研究将围绕对基础表面/界面科学至关重要的三个关键主题展开。 目标和方法 1.用于(生物)传感平台的AuNPs：将开发两种新的多路形式的轻便传感器方案，将我们最新开发的用于通道波导定义的AuNP条带加载技术与最近发现和描述的局域表面等离子体共振的线宽窄化效应相结合。将通过开发AuNP传感器平台的回收方法(使用后安全处置)来解决AuNPs的健康和环境问题。 2.(Bio)-界面、涂层和胶原膜：涉及在植入物上制造高度定向的胶原膜，以增强生物相容性，避免宿主排斥反应，并利用其物理特性模拟各向异性组织。将建立一种具有圆形闭合势垒的新型Langmuir-Blodgett(LB)沟槽设计。此外，还将开发一种制备自立式定向胶原膜的技术。有了这些独立的薄膜，可能会有多层的新的角膜植入策略成为可能。 3.波导消失场显微镜：将开发一种动态操作的消逝显微镜和由聚合物(刚性和柔性)制成的新型高光学质量的波导芯片，以研究和提高细胞与技术表面的粘附性(对医疗植入物很重要)。还设想了开发微型婴儿起搏器的科学基础。 意义和影响 此外，HQP还在多学科背景下接受了关于最新技术和R高科技R的出色培训，以及对加拿大经济财富和生活的影响。