Photonics of Surfaces and Interfaces

表面和界面光子学

• 批准号: RGPIN-2019-05908
• 负责人: Mittler, Silvia
• 金额: $ 2.62万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=763051
• 关键词: Photonics; Surfaces; Interfaces

INTRODUCTION My research program is focused on the study and design of novel surfaces and interfaces using waveguides and plasmonics, which exhibit a thin film of light (called evanescent field) directly located at a surface or an interface to an adjacent object. In nano-plasmonics, metal nanoparticles (NPs) show a very strong film of light and a strong absorption band, allowing colorimetric or transmission devices for high sensitivity chemical sensors. The light films are also applied in surface microscopy. Scattering/fluorescence evanescent microscopy is used to study surfaces and interfaces, coatings, bacteria film formation and single cell-substratum interaction. My group is known world-wide for its highly sophisticated, interdisciplinary research and achievements through many scientific contributions in form of high impact publications, outstanding conference contributions and well-trained students with their own success stories. My research will center around three key themes critical for fundamental surface/interface science. OBJECTIVES AND APPROACHES 1.AuNPs for (Bio)-Sensing Platforms: two new lean and facile sensor schemes in multiplexing form integrating our newly developed AuNP-strip-loading technology for channel waveguide definition as well as the recently discovered and described (by us) line-width narrowing effect of the localized surface plasmon resonance will be developed. Health and environmental issues of AuNPs will be addressed by developing a recycling method for the AuNP sensor platforms (safe disposal after use). 2.(Bio)-Interfaces, Coatings and Collagen Films: involves the fabrication of highly oriented collagen films on implants for an enhanced biocompatibility, avoiding the host rejection, and the mimicking of anisotropic tissue with its physical characteristics. A novel Langmuir-Blodgett (LB) trough design with a circularly closing barrier will be established. In addition, a technology to fabricate free-standing oriented collagen films will be developed. With these free-standing films, possibly multilayered, new cornea implant strategies should be enabled. 3. Waveguide Evanescent Field Microscopy: a dynamically operating evanescent microscope and novel high optical quality waveguide chips fabricated from polymers (stiff and flexible) will be developed to allow studying and enhancing the adhesion-quality of cells to technical surfaces (important for medical implants). Also envisioned is the scientific groundwork for developing a miniaturized infant pace maker. SIGNIFICANCE AND IMPACT Besides the excellent training of HQP in a multidisciplinary setting on state-of-the-art technology and R&D strategies, possible translation to Canadian industry, and the publications in peer-reviewed, high impact journals, this research program will enhance and foster Canada's high tech R&D now and in the future, and will therefore be contributing actively to Canada's economic wealth and to Canadian life.

引言我的研究计划主要集中在研究和设计新颖的表面和界面使用波导和等离子体，它表现出一个薄膜的光（称为倏逝场）直接位于一个表面或界面到相邻的对象。在纳米等离子体中，金属纳米颗粒（NPs）显示出非常强的光膜和强吸收带，允许用于高灵敏度化学传感器的比色或透射装置。该光膜还可用于表面显微镜。散射/荧光渐逝显微镜用于研究表面和界面，涂层，细菌膜形成和单细胞基质相互作用。我的团队以其高度复杂的跨学科研究和成就而闻名于世，通过高影响力出版物，杰出的会议贡献和训练有素的学生以及他们自己的成功故事的形式做出了许多科学贡献。我的研究将围绕三个关键主题的关键基础表面/界面科学。1.AuNPs用于（生物）传感平台：将开发两种新的多路复用形式的精益和简易传感器方案，其集成了我们新开发的用于通道波导定义的AuNP-strip-loading技术以及最近发现和描述的（由我们）局部表面等离子体共振的线宽窄化效应。AuNP的健康和环境问题将通过开发AuNP传感器平台的回收方法（使用后安全处置）来解决。2.（生物）-界面、涂层和胶原蛋白膜：涉及在植入物上制造高度定向的胶原蛋白膜，以增强生物相容性，避免宿主排斥反应，并模仿具有物理特性的各向异性组织。将建立一种具有圆形封闭屏障的新型LB槽设计。此外，还将开发一种制造自支撑取向胶原膜的技术。有了这些独立的薄膜，可能是多层的，新的角膜植入策略应该是可行的。 3.波导倏逝场显微镜：将开发一种动态操作的倏逝场显微镜和由聚合物（刚性和柔性）制成的新型高光学质量波导芯片，以研究和提高细胞在技术表面的粘附质量（对医疗植入物很重要）。还设想了开发小型婴儿起搏器的科学基础。 除了在多学科环境中对HQP进行关于最先进的技术和研发战略的优秀培训，可能的翻译加拿大工业，以及在同行评审的高影响力期刊上发表文章外，该研究计划将加强和促进加拿大现在和未来的高科技研发，因此将积极为加拿大的经济财富和加拿大人的生活做出贡献。