Laboratory for Photonics of Surfaces and Interfaces

表面与界面光子学实验室

• 批准号: RGPIN-2014-05793
• 负责人: Mittler, Silvia
• 金额: $ 3.13万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632249
• 关键词: Laboratory; Photonics; Surfaces; Interfaces

Summary of ProposalThe Laboratory for Photonics of Surfaces and Interfaces (LoPSI)Surface and interface science is gaining more interest and increasing importance. It is a highly interdisciplinary field and spans from fundamental sciences such as physics, chemistry, and biology to the applied sciences and into daily life. Typical applications - just to name a few -are chemical and biochemical sensors, self-cleaning surfaces and tissue engineering. Surfaces play a major role in all aspects of nanotechnology but also on all macroscopic and technical surfaces. A typical example of a still unsolved problem with many aspects of interdisciplinary surface science is the growth of "sea creatures" on ships called bio-fouling. The fuel consumption increases rapidly with increasing biomass. An anti-fouling paint would have an enormous impact on sea-logistics. The calcification of heart valves, the knowledge of the adhesion strength and quality between a cell and an implant or sturdy antibacterial coatings avoiding salmonella outbreaks in food plants or water works are other examples in this context needing fundamental scientific input. Among a variety of well-established techniques for surface and interface research is the remarkable set of optical approaches based on waveguides and plasmonic devices showing a thin film of light (an evanescent field) directly located at the point of interest: the surface. In nano-plasmonics, metal nanoparticles (NPs) show a very strong film of light in conjunction with a strong absorption band allowing simple colorimetric devices with application in high sensitivity chemical sensing. The surface photonics are also applied in surface microscopy. Scattering and fluorescence evanescent microscopies are now available to study surfaces and interfaces, coatings, artificial bio-membranes, biofilm formation (bacteria), and single cell-substratum interaction. The LoPSI is known world-wide for its highly sophisticated, interdisciplinary research program and achievements through many scientific contributions in form of high impact publications, patents, and outstanding conference contribution. The LoPSI carries expertise in ultra-thin and thin film physics, chemistry and biology (from monolayers to bio-membranes).One aim is the fabrication of highly oriented collagen films in layered form, mimicking the cornea's internal structure, with a size in the order of 1 cm2. With these multilayered films cornea reconstruction in the human eye should be enabled (e.g. glaucoma patients). With the aid of these photonic and plasmonic tools and combinations thereof, ultrathin natural and engineered films as well as living cells and biofilms located on surfaces will be detected, characterized, and imaged microscopically based on their specific optical predicates. In the current proposal the focus lies on the development of novel high optical quality waveguide chips fabricated out of glass or from polymers. These waveguide chips will be used for gold NP bio-sensing (cancer markers), for evanescent microscopy in particular to allow studying and enhancing the adhesion-quality of cells to a technical (implant) surface. One future aim is a miniaturized infant pace maker. Re-usable glass chip will be developed to foster the use of the novel microscopy technology, iter alia for stem cell research. During the 5 year period graduate students, MSc and PhD, will be excellently trained on state-of-the-art technology and R&D strategies which will advance, enhance and foster Canada's high tech R&D now and in the future; therefore contributing actively to Canada's economic wealth and to a Canadian life.

表面和界面光子学实验室（LoPSI）表面和界面科学越来越受到人们的关注和重视。它是一个高度跨学科的领域，从物理学，化学和生物学等基础科学到应用科学和日常生活。典型的应用-仅举几例-是化学和生物化学传感器，自清洁表面和组织工程。表面在纳米技术的各个方面都发挥着重要作用，但也在所有宏观和技术表面上。一个典型的例子，仍然没有解决的问题，许多方面的跨学科表面科学是生长的“海洋生物”的船舶上所谓的生物污垢。随着生物量的增加，燃料消耗迅速增加。防污油漆将对海上物流产生巨大影响。心脏瓣膜的钙化、细胞和植入物之间的粘附强度和质量的知识或防止食品厂或自来水厂中沙门氏菌爆发的坚固抗菌涂层是这方面需要基础科学投入的其他例子。在表面和界面研究的各种成熟技术中，有一套引人注目的光学方法，该方法基于波导和等离子体激元器件，显示出直接位于感兴趣点（表面）的光薄膜（倏逝场）。在纳米等离子体中，金属纳米颗粒（NP）显示出非常强的光膜以及强吸收带，从而允许简单的比色装置在高灵敏度化学传感中应用。表面光子学也应用于表面显微镜。散射和荧光渐逝显微镜现在可用于研究表面和界面，涂层，人工生物膜，生物膜形成（细菌），和单细胞基质相互作用。LoPSI以其高度复杂的跨学科研究计划和成就而闻名于世，并通过高影响力出版物，专利和杰出会议贡献的形式做出了许多科学贡献。LoPSI拥有超薄和薄膜物理学、化学和生物学（从单层到生物膜）方面的专业知识，其目标之一是制造高度定向的分层胶原膜，模仿角膜的内部结构，尺寸约为1 cm 2。利用这些多层膜，应该能够在人眼中进行角膜重建（例如青光眼患者）。借助于这些光子和等离子体激元工具及其组合，将基于其特定的光学等同物来检测、表征和显微成像位于表面上的生物天然和工程化膜以及活细胞和生物膜。在目前的建议，重点在于开发新型的高光学质量的波导芯片制造的玻璃或聚合物。这些波导芯片将用于金NP生物传感（癌症标记），特别是用于倏逝显微镜，以允许研究和增强细胞对技术（植入物）表面的粘附质量。未来的一个目标是小型化婴儿起搏器。将开发可重复使用的玻璃芯片，以促进新的显微镜技术的使用，阿利亚是用于干细胞研究。在5年期间，硕士和博士研究生将接受最先进的技术和研发战略的出色培训，这将推动，加强和促进加拿大现在和未来的高科技研发;因此，积极为加拿大的经济财富和加拿大生活做出贡献。