Nanomaterial impacts on the gastrointestinal microbiome.

纳米材料对胃肠道微生物群的影响。

• 批准号: RGPIN-2019-06596
• 负责人: Prakash, Satya
• 金额: $ 3.35万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=715049
• 关键词: Nanomaterial; impacts; gastrointestinal; microbiome.

Recent technological advances have led to various nanomaterials being developed for use in food, medicine, electronics, fuels, consumer products, etc. Because of these innovations, humans are increasingly being exposed to significant amounts of these nanomaterials, specifically via food and food-packaging. Ingestion of nanomaterials has consequential impacts on the gastrointestinal tract and leads to interactions with the gut microflora. The nanomaterials most commonly found in food, food pigments, drinks, food packaging, toothpaste, toothbrushes, e-cigarettes and even baby bottles and pacifiers, include zinc oxide nanoparticles (ZnO-NPs), titanium dioxide nanoparticles (TiO2-NPs), silver nanoparticles (AgNPs) and nanosilica (SiO2). Based on the minimum and maximum concentrations of these nanomaterials permitted in food and related products, our plan is to conduct in-vitro and in-vivo studies to evaluate their impact on the gut microbiome. Nanomaterials are powerful industrial materials and there has been rapid growth for their use in consumer products, chemical, biochemical and other industries. Despite these benefits of nanomaterials, the environmental impact and effects on human health through gastrointestinal exposure and other means are poorly understood. The aim of this research program is to perform fundamental research and investigations surrounding the impact of nanomaterials on the gastrointestinal microbiome. This study will help us to understand the basic mechanism of these interactions and advance the fundamental knowledge of nanomaterial impacts on environmental and human health. The problems addressed are motivated and defined by the requirements of fundamental chemical, bioengineering, food science, material science and nanotechnology research and technology developments. This research program will provide excellent opportunities for the training of highly qualified personal in these high-priority industrial areas.

最近的技术进步导致各种纳米材料被开发用于食品，医药，电子，燃料，消费品等，由于这些创新，人类越来越多地接触到大量的这些纳米材料，特别是通过食品和食品包装。纳米材料的摄入对胃肠道产生了相应的影响，并导致与肠道微生物菌群的相互作用。食品、食品色素、饮料、食品包装、牙膏、牙刷、电子烟甚至婴儿奶瓶和奶嘴中最常见的纳米材料包括氧化锌纳米颗粒（ZnO-NPs）、二氧化钛纳米颗粒（TiO 2-NPs）、银纳米颗粒（AgNPs）和纳米二氧化硅（SiO2）。根据食品和相关产品中允许的这些纳米材料的最低和最高浓度，我们计划进行体外和体内研究，以评估它们对肠道微生物组的影响。纳米材料是一种功能强大的工业材料，在消费品、化工、生物化工等行业的应用增长迅速。尽管纳米材料有这些好处，但人们对环境影响以及通过胃肠道接触和其他方式对人类健康的影响知之甚少。该研究计划的目的是围绕纳米材料对胃肠道微生物组的影响进行基础研究和调查。这项研究将有助于我们了解这些相互作用的基本机制，并推进纳米材料对环境和人类健康影响的基础知识。所解决的问题是由基础化学，生物工程，食品科学，材料科学和纳米技术研究和技术发展的要求所激发和定义的。该研究计划将为这些高优先级工业领域的高素质人才的培训提供绝佳的机会。