Carbon nanotube bacterial cell interactions: development of carbon nanotube formulations for targeted destruction of pathogenic antibiotic resistant bacterial cells.

碳纳米管细菌细胞相互作用：开发碳纳米管制剂，用于有针对性地破坏致病性抗生素耐药细菌细胞。

• 批准号: 239094-2012
• 负责人: Prakash, Satya
• 金额: $ 3.28万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514432
• 关键词: Carbon; nanotube; bacterial; cell; interactions

Antibiotic-resistant pathogenic bacteria are a major concern today, in the fields of animal, human and environmental health. This research program concerns with the development of multifunctional carbon nanotubes (CNTs) formulations with the specific aim of targeted destruction of antibiotic resistant pathogenic bacterial cells. The problems addressed are motivated and defined by requirements of the fundamental material science, chemistry and nanotechnology research and biomedical technology developments. The research also addresses the fundamental issues of nanomaterial bacterial cell interactions. Nanomaterials are powerful industrial materials and there has been rapid growth in nanotechnology research for use in chemical, biochemical, healthcare and other industries. However, environmental, food chain and human health exposures of the nanomaterials like CNTs are yet to be fully understood. In such an event the CNTs are most likely to interact first with environmental and GI bacterial cells and such an interaction warrants detailed investigation. The research aim is to perform fundamental and applied research and investigate carbon nanotube gastrointestinal bacterial cell interactions. This study will help understand the basic mechanisms of nanomaterial interactions with bacterial cells and will contribute to the advancement of fundamental knowledge of nanomaterial impacts on environmental, animal and human health. If successful, this research will result in CNT therapies to combat antibiotic resistance pathogenic bacterial cells. This research will provide several opportunities for training of highly qualified personal.

抗生素抗性病原菌是当今动物、人类和环境健康领域的主要关注点。该研究计划涉及多功能碳纳米管（CNT）制剂的开发，其特定目的是靶向破坏抗生素耐药性致病细菌细胞。所解决的问题是由基础材料科学，化学和纳米技术研究以及生物医学技术发展的要求所激发和定义的。该研究还解决了纳米材料细菌细胞相互作用的基本问题。纳米材料是一种功能强大的工业材料，用于化学、生物化学、医疗保健和其他行业的纳米技术研究迅速增长。然而，环境，食物链和人类健康暴露的纳米材料，如碳纳米管尚未完全了解。 在这种情况下，碳纳米管最有可能首先与环境和胃肠道细菌细胞相互作用，这种相互作用需要进行详细的研究。本研究的目的是进行基础和应用研究，并探讨碳纳米管胃肠道细菌细胞的相互作用。这项研究将有助于了解纳米材料与细菌细胞相互作用的基本机制，并将有助于推进纳米材料对环境，动物和人类健康影响的基础知识。如果成功，这项研究将导致CNT疗法来对抗抗生素耐药性致病细菌细胞。这项研究将为培养高素质的人才提供几个机会。