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Examining the role for natural killer cell TGFb signaling in pulmonary vascular development and the pathogenesis of pulmonary hypertension

Examining the role for natural killer cell TGFb signaling in pulmonary vascular development and the pathogenesis of pulmonary hypertension
检查自然杀伤细胞 TGFb 信号传导在肺血管发育和肺动脉高压发病机制中的作用
批准号：
452132
负责人：
Ormiston Mark L
金额：
$54.66万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=452132&lang=en
关键词：
Conditional Knockout Mouse Models Immunity Natural Killer Cells Pulmonary Arterial Hypertension Pulmonary Vascular Development Single Cell Rna Sequencing Transforming Growth Factor-B

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Pulmonary arterial hypertension (PAH) is a fatal disease that preferentially targets young females. The disease involves a loss of lung blood vessels, leading to increased stress on the right heart and eventual death due to heart failure. Our research has
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