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Role of the E2F1 transcription factor in TGFß-mediated signal transduction

Role of the E2F1 transcription factor in TGFß-mediated signal transduction
E2F1 转录因子在 TGFα 介导的信号转导中的作用
批准号:
224157
负责人:
Lebrun Jean-Jacques
金额:
$48.19万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-03-01 至 2016-03-01

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中文摘要
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英文摘要
Growth factors from the transforming growth factor-ß (TGFß) induce cell death, block cell proliferation and prevent cell immortalization in most human tissues. Thus, they block the growth of the cells and their main role is to act as safeguards to prevent
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Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer
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    469188
  • 项目类别:
    Operating Grants
  • 资助金额:
    $88.89万
  • 财政年份:
    2022
  • 负责人:
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  • 依托单位:
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
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    461405
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    Operating Grants
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    $76.24万
  • 财政年份:
    2022
  • 负责人:
    Lebrun Jean-Jacques
  • 依托单位:
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
  • 批准号:
    455857
  • 项目类别:
    Operating Grants
  • 资助金额:
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  • 财政年份:
    2021
  • 负责人:
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Characterization of the TGFß microRNAome - implications for new biomarkers and therapeutic targets in human cancer
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