Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer
利用新型双特异性细胞周期抑制剂 KP108 作为转移性乳腺癌的治疗方法
基本信息
- 批准号:469188
- 负责人:
- 金额:$ 88.89万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-09-01 至 2027-09-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Metastatic cancers are the most aggressive cancers, accounting for 90% of all cancer-related deaths. Radiation as well as chemotherapy are not effective enough to fight against these types of cancers. It is now clearly established that there is a link bet
转移性癌症是最具侵袭性的癌症,占所有癌症相关死亡的90%。放疗和化疗都不足以有效地对抗这些类型的癌症。现在已经明确成立,存在链接投注
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lebrun Jean-Jacques其他文献
Lebrun Jean-Jacques的其他文献
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{{ truncateString('Lebrun Jean-Jacques', 18)}}的其他基金
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
定义 CDK6 和 DNA 修复途径在肿瘤发生中的作用,并确定三阴性乳腺癌中依赖于 CDK4/6 的合成致死漏洞。
- 批准号:
461405 - 财政年份:2022
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
定义 CDK6 和 DNA 修复途径在肿瘤发生中的作用,并确定三阴性乳腺癌中依赖于 CDK4/6 的合成致死漏洞。
- 批准号:
455857 - 财政年份:2021
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
Characterization of the TGFß microRNAome - implications for new biomarkers and therapeutic targets in human cancer
TGF™ microRNAome 的表征 - 对人类癌症新生物标志物和治疗靶点的影响
- 批准号:
346700 - 财政年份:2016
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
CDK4 regulation of breast cancer stem cells - A novel prognostic marker and therapeutic target for triple-negative breast cancer and chemotherapy-resistant tumors.
CDK4对乳腺癌干细胞的调节——三阴性乳腺癌和化疗耐药肿瘤的新型预后标志物和治疗靶点。
- 批准号:
345984 - 财政年份:2016
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
Role of the E2F1 transcription factor in TGFß-mediated signal transduction
E2F1 转录因子在 TGFα 介导的信号转导中的作用
- 批准号:
224157 - 财政年份:2011
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
Novel functions for p21 and cyclinD1 in TGFB-mediated breast cancer metastasis
p21 和 cyclinD1 在 TGFB 介导的乳腺癌转移中的新功能
- 批准号:
199790 - 财政年份:2010
- 资助金额:
$ 88.89万 - 项目类别:
Operating Grants
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Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors
种族和民族对接受 CDK4/6 抑制剂治疗的激素受体阳性乳腺癌患者预后的影响
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推进NF1-MPNST的RAS通路靶向治疗:SHP2和CDK4/6抑制剂对肿瘤和肿瘤免疫微环境的影响
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10660326 - 财政年份:2023
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$ 88.89万 - 项目类别:
Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors
种族和民族对接受 CDK4/6 抑制剂治疗的激素受体阳性乳腺癌患者预后的影响
- 批准号:
10762047 - 财政年份:2023
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Developing personalized therapy for breast cancer based on elucidating mechanisms of resistance to CDK4/6 inhibitors using single-cell
利用单细胞阐明 CDK4/6 抑制剂的耐药机制,开发乳腺癌的个性化治疗
- 批准号:
22K16444 - 财政年份:2022
- 资助金额:
$ 88.89万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
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靶向 6-Phosphofructo-2-Kinase 以提高 CDK4/6 抑制剂的功效
- 批准号:
10650304 - 财政年份:2020
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Targeting 6-Phosphofructo-2-Kinase to increase efficacy of CDK4/6 Inhibitors
靶向 6-Phosphofructo-2-Kinase 以提高 CDK4/6 抑制剂的功效
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10052862 - 财政年份:2020
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Targeting 6-Phosphofructo-2-Kinase to increase efficacy of CDK4/6 Inhibitors
靶向 6-Phosphofructo-2-Kinase 以提高 CDK4/6 抑制剂的功效
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10430005 - 财政年份:2020
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Targeting 6-Phosphofructo-2-Kinase to increase efficacy of CDK4/6 Inhibitors
靶向 6-Phosphofructo-2-Kinase 以提高 CDK4/6 抑制剂的功效
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10213670 - 财政年份:2020
- 资助金额:
$ 88.89万 - 项目类别:
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通过雄激素信号验证的 CDK4/6 抑制剂治疗乳腺癌的新策略
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19K18038 - 财政年份:2019
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