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Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer

Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer
利用新型双特异性细胞周期抑制剂 KP108 作为转移性乳腺癌的治疗方法
批准号：
469188
负责人：
Lebrun Jean-Jacques
金额：
$88.89万
依托单位：
McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=469188&lang=en
关键词：
Cancer Stem Cell Therapy Cdk4/6 Inhibitors Computational Modeling Drug Development Dual Targeting Kinase Inhibitors Metastatic Cancer Plk1 Inhibitors Preclinical Models Of Breast Cancer Structure-Based Drug Discovery And Design Triple Negative Br

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英文摘要
Metastatic cancers are the most aggressive cancers, accounting for 90% of all cancer-related deaths. Radiation as well as chemotherapy are not effective enough to fight against these types of cancers. It is now clearly established that there is a link bet
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Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
  • 批准号：
    461405
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    Operating Grants
  • 资助金额：
    $76.24万
  • 财政年份：
    2022
  • 负责人：
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  • 依托单位：
    McGill University Health Centre
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
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    455857
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    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2021
  • 负责人：
    Lebrun Jean-Jacques
  • 依托单位：
    McGill University Health Centre
Characterization of the TGFß microRNAome - implications for new biomarkers and therapeutic targets in human cancer
CDK4 regulation of breast cancer stem cells - A novel prognostic marker and therapeutic target for triple-negative breast cancer and chemotherapy-resistant tumors.
  • 批准号：
    345984
  • 项目类别：
    Operating Grants
  • 资助金额：
    $71.57万
  • 财政年份：
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  • 负责人：
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  • 依托单位：
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