Actin cytoskeleton: Regulation through protein interactions and epigenetic re-programming

肌动蛋白细胞骨架:通过蛋白质相互作用和表观遗传重编程进行调节

基本信息

  • 批准号:
    RGPIN-2020-05388
  • 负责人:
  • 金额:
    $ 3.64万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

The shape of each cell in the human body is determined by an internal structure called the cytoskeleton, which is a network of interconnected proteins that provides a "load-bearing" structure that enables movement and provides protection from potentially damaging external forces. Two of the most important cytoskeleton proteins are actin and myosin. Individual actin molecules can be joined together to form long fibres. Myosin is a large protein complex, composed of 2 heavy chains, 2 essential light chains and 2 regulatory light chains. Actin fibres and myosin complexes bind to each other, and when myosin is activated it pulls on the actin fibres they are bound to, shortening the length of actin-myosin fibres and leading to tension in the cytoskeleton network. Since the cytoskeleton is responsible for protecting cells from damaging external forces, it is important for cells to adjust the physical strength of their cytoskeleton to adapt to changing environments. An important way that cells reinforce their cytoskeleton is to activate the myosin complex to shrink the length of actin-myosin fibres. This actin-myosin fibre shortening produces cytoskeleton tension that makes cells physically stiffer. In addition to myosin activation, there may be changes in the collection of proteins that are associated with the cytoskeleton. In this proposal, we will identify the proteins that are part of the cytoskeleton when it is relaxed, and discover how the collection of associated proteins changes when the cytoskeleton becomes tense. If the environment undergoes long term changes in how it exerts pressure on cells, cells may compensate by rapidly changing how specific genes are expressed, and even by modifying their DNA to alter the long-term expression of genes that contribute to the cytoskeleton's physical strength. In this proposal, we will determine if cells “re-wire” their DNA to change gene expression patterns if cytoskeleton tension is prolonged, and we will identify the cytoskeleton-related genes that are expressed differently as a result of these DNA alterations. The experiments in this proposal will be the first to systematically examine how the complex of proteins in the cytoskeleton changes between the relaxed and contracted states, and how sustained cytoskeleton contraction alters the expression of genes encoding for proteins related to cytoskeleton organization and function. The proposed research will benefit Canadians by: 1) Leading to novel discoveries in cell biology and cytoskeleton regulation that will enhance Canada's scientific reputation and innovation potential; 2) Training of highly-qualified personnel to expand their career perspectives and increase future employability in academic or industrial biomedical research so that they may contribute to Canada's knowledge economy; 3) Development of novel multi-disciplinary approaches and generation of unique biological research tools that will be shared with the Canadian research community.
人体中每个细胞的形状都是由一个叫做细胞骨架的内部结构决定的,细胞骨架是一个相互连接的蛋白质网络,它提供了一个“承重”结构,使运动成为可能,并提供保护,免受潜在的破坏性外力。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Olson, Michael其他文献

Flexion-relaxation response to gravity
  • DOI:
    10.1016/j.jbiomech.2005.09.009
  • 发表时间:
    2006-01-01
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Olson, Michael;Solomonow, Moshe;Li, Li
  • 通讯作者:
    Li, Li
Succeeding in Rural Mental Health Practice: Being Sensitive to Culture by Fitting in and Collaborating
  • DOI:
    10.1007/s10591-013-9287-x
  • 发表时间:
    2014-03-01
  • 期刊:
  • 影响因子:
    1.3
  • 作者:
    Bischoff, Richard J.;Reisbig, Allison M. J.;Olson, Michael
  • 通讯作者:
    Olson, Michael
Genomic Study on Blood Culture Isolates From Patients With Staphylococcus Infection-associated Glomerulonephritis.
  • DOI:
    10.1016/j.ekir.2022.07.010
  • 发表时间:
    2022-10
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Rana, Pranav S. J. B.;Aljabban, Jihad;Prarat, Melanie;Pancholi, Preeti;Balada-Llasat, Joan Miquel;Stephens, Julie;Webb, Amy;Chen, Liang;Brodsky, Sergey, V;Nadasdy, Tibor;Zhang, Yan;Parikh, Samir, V;Wozniak, Daniel J.;Wang, Shu-Hua;Olson, Michael;Satoskar, Anjali A.
  • 通讯作者:
    Satoskar, Anjali A.
On the relationship between automatic attitudes and self-reported sexual assault in men.
  • DOI:
    10.1007/s10508-012-9970-2
  • 发表时间:
    2013-07
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Widman, Laura;Olson, Michael
  • 通讯作者:
    Olson, Michael

Olson, Michael的其他文献

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{{ truncateString('Olson, Michael', 18)}}的其他基金

Actin cytoskeleton: Regulation through protein interactions and epigenetic re-programming
肌动蛋白细胞骨架:通过蛋白质相互作用和表观遗传重编程进行调节
  • 批准号:
    RGPIN-2020-05388
  • 财政年份:
    2022
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Actin cytoskeleton: Regulation through protein interactions and epigenetic re-programming
肌动蛋白细胞骨架:通过蛋白质相互作用和表观遗传重编程进行调节
  • 批准号:
    RGPIN-2020-05388
  • 财政年份:
    2021
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
embedded systems
嵌入式系统
  • 批准号:
    529724-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Experience Awards (previously Industrial Undergraduate Student Research Awards)
Reinforcement Pulps & Pulp and Paper Products
增强纸浆
  • 批准号:
    468917-2014
  • 财政年份:
    2014
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Experience Awards (previously Industrial Undergraduate Student Research Awards)

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Regulation of GluN2B-NMDA Receptors by Interactions with the Actin Cytoskeleton
通过与肌动蛋白细胞骨架相互作用调节 GluN2B-NMDA 受体
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