Upgrade to the UBC Environmental Physiology Laboratory to include Ozone Exposure Capacity

空气污染会导致多种健康状况和疾病，同时，运动和体力活动是预防和治疗疾病的重要手段。然而，在许多空气质量很差的社区，人们担心运动会增加污染剂量，并可能对人体造成不良影响。然而，人们对空气污染物与人体机能之间的相互作用知之甚少。 空气污染是固体和液体颗粒以及气体的混合物。这种混合物因地点、时间、天气和季节而异。在过去，我们已经做了很多研究，以表征柴油尾气如何影响人类对运动的反应。 然而，有一种污染物我们还无法测试，那就是地面臭氧。这是一种由太阳对其他污染物进行修饰而产生的气体。它出现在城市和交通中，通常是在炎热和阳光明媚的日子里。臭氧似乎比其他污染物对呼吸系统的影响更大，无论是对健康人还是哮喘患者。有趣的是，随着时间的推移，人类可能有适应臭氧的能力。 因此，需要研究了解臭氧在运动过程中如何与人体相互作用，以及人类通过什么机制来适应臭氧。这项工作的结果不仅可以帮助我们了解臭氧对人体的影响，还可以就如何最好地适应臭氧提出建议或战略。 我们有用其他类型的污染物进行污染暴露研究的长期记录，但没有能力用臭氧进行这项工作。目前，我们知道加拿大的设施能够在人体运动期间提供安全的臭氧暴露。拟议的赠款将用于升级我们现有的设施，使我们能够提供这种能力。该设备将是模块化的，这样它就可以在共同申请者的实验室之间移动，用于不同的应用，从大气化学到更具侵入性的研究，涉及从肺部采集样本。

Air pollution can lead to a variety of health conditions and diseases, while at the same time, exercise and physical activity are important means of preventing and treating disease. However, in many communities where air quality is poor much of the time, there is a concern that exercise can increase the dose of pollution and possibility the ill effects of pollution on the human body. However, the interaction between air pollutants and human function is poorly understood. Air pollution is a mix of solid and liquid particles, and gases. This mixture varies by location, time of day, weather and season. In the past we have done a lot of research to characterise how diesel exhaust affects the human response to exercise. However, one pollutant that we have not yet been able to test is ground level ozone. This is a gas that is created by the modification of other pollutants by the sun. It is present in cities and traffic, typically on hot and sunny days. Ozone seems to affect the respiratory system more than other pollutants, in both healthy people and those with asthma. Interestingly, humans might to have an ability to adapt to ozone over time though. Therefore, research is required to understand how ozone interacts with the human body during exercise and what is the mechanism by which humans can adapt to ozone. The results of this work could help us not only understand how ozone affects the human body, but also can lead to recommendations or strategies on how best to adapt to ozone. We have a long track record of conducting pollution exposure studies with other types of pollutants, but do not have the capability to do this work with ozone. Currently, we know of now facilities in Canada capable of providing a safe ozone exposure during exercise in humans. The proposed grant would fund upgrades to our existing facilities that would allow us to provide that capability. The equipment would be modular so it could be moved between the laboratories of the co-applicants for different applications from atmospheric chemistry to more invasive research involving collecting samples from within the lungs.